28 March 2024>: Clinical Research
Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Predicting Complete Pathological Response in Rectal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy
Mustafa Karaca 1ACDEF* , Ece Salim 2ABDEF , Mustafa Serkan Alemdar 3BDEF , Özge Deniz Karaca 2BEF , Mustafa Özgür Arıcı 3BDEFDOI: 10.12659/MSM.943750
Med Sci Monit 2024; 30:e943750
Table 6 Factors associated with progression-free survival of patients.
Variables | Univariate | Multivariate | ||
---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | |
Age | 1.022 (0.999–1.045) | 0.05.8 | 1.02 (0.998–1.043) | 0.074 |
Male gender | 1.755 (1.027–3) | 1.693 (0.976–2.937) | 0.061 | |
Comorbid disease | 0.748 (0.454–1.231) | 0.253 | – | – |
Chemotherapy agent | ||||
Capecitabine | Reference | – | Reference | – |
5-FU | 1.981 (1.221–3.215) | 1.941 (1.165–3.234) | ||
Type of surgery | ||||
LAR | Reference | – | – | – |
MILES operation | 1.318 (0.755–2.301) | 0.332 | – | – |
Hemoglobin at diagnosis | 0.972 (0.865–1.091) | 0.626 | – | – |
Platelets at diagnosis | 1.001 (0.998–1.004) | 0.489 | – | – |
LDH at diagnosis | 1.003 (0.998–1.007) | 0.228 | – | – |
NLR at diagnosis >3.63 | 1.911 (1.187–3.077) | 1.314 (0.784–2.204) | 0.300 | |
HR – hazard ratio; CI – confidence interval; 5-FU – 5-Fluorouracil; LAR – low anterior resection; LDH – lactate dehydrogenase; NLR – neutrophil/lymphocyte ratio. |