28 March 2024 : Clinical Research
Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Predicting Complete Pathological Response in Rectal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy
Mustafa Karaca
1ACDEF, Ece Salim2ABDEF, Mustafa Serkan Alemdar 3BDEF, Özge Deniz Karaca 2BEF, Mustafa Özgür Arıcı 3BDEF*
DOI: 10.12659/MSM.943750
Med Sci Monit 2024; 30:e943750
Table 7 Factors associated with overall survival of patients.
| Variables | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | |
| Age | 1.035 (1.004–1.068) | 1.04 (1.007–1.073) | ||
| Male gender | 1.312 (0.683–2.519) | 0.415 | ||
| Comorbid disease | 0.538 (0.27–1.071) | 0.078 | 0.474 (0.234–1.018) | 0.065 |
| Chemotherapy agent | ||||
| Capecitabine | Reference | – | Reference | – |
| 5-FU | 2.097 (1.104–3.982) | 2.188 (1.129–4.238) | ||
| Type of surgery | ||||
| LAR | Reference | – | Reference | – |
| MILES operation | 2.347 (1.239–4.446) | 0.009 | 2.11 (1.097–4.055) | |
| Hemoglobin at diagnosis | 0.904 (0.78–1.048) | 0.904 | – | – |
| Platelets at diagnosis | 1 (0.996–1.003) | 0.853 | – | – |
| LDH at diagnosis | 1.003 (0.998–1.009) | 0.246 | – | – |
| NLR at diagnosis >3.63 | 1.724 (0.934–3.181) | 0.082 | 1.144 (0.604–2.167) | 0.680 |
| HR – hazard ratio; CI – confidence interval; 5-FU – 5-Fluorouracil; LAR – low anterior resection; LDH – lactate dehydrogenase; NLR – neutrophil/lymphocyte ratio. | ||||