28 January 2024 : Review article
A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and Future
Dinah V. Parums1CDEF*DOI: 10.12659/MSM.943912
Med Sci Monit 2024; 30:e943912
Background
The First Identified Systemic Vasculitis: IgA Vasculitis, or Henoch-Schönlein Purpura
Current Classification Criteria and Clinical Guidelines
Epidemiology of IgA Vasculitis
Risk Factors for IgA Vasculitis
Clinical Presentation in Children
Clinical Presentation in Adults
Diagnosis of IgA Vasculitis
Mechanisms in the Pathogenesis of IgA Vasculitis
Future Studies and Unmet Clinical Needs
Conclusions
References
Table 1 Risk factors for IgA vasculitis [36,38,41–43,52,59].
| Bacterial infections | Group A Streptococcus (most common) |
| Parasites and yeasts | |
| Viral infections | ParvovirusAdenovirusEpstein-Barr virus (EBV)Varicella-zoster virus (VZV)Rotavirus |
| Allergens | Insect bitesHorse serum |
| Drugs and antibiotics | QuinineDalimumabAmpicillinCytarabineErythromycinInfliximabPenicillinTegafur/Gimeracil/Oteracil (S-1) |
| Vaccines | Hepatitis BInfluenzaYellow feverMeasles, mumps, rubella (MMR)SARS-CoV-2 (COVID-19) |
| Physical agents | HypothermiaBurns |