Shortening Oral Simethicone-to-Colonoscopy Interval Increases Bowel Preparation Quality

22 June 2024 : Clinical Research

Rongrong Cao^1BCDEF, Fanjun Meng^1BCD, Chengkun Li^1B, Hongxin Chen^1E, Cong Gao^1B, Hongyu Li^1E, Xingshun Qi^1ABCDEFG*

DOI: 10.12659/MSM.943972

Med Sci Monit 2024; 30:e943972

Introduction Material and Methods Results Discussion Conclusions References

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Table 1 Baseline characteristics of included patients in the training cohort.

Variables	Overall (N=364)	Short S-C group (N=182)	Long S-C group (N=182)	P value
Variables	Median (range) or Frequency (percentage)	Median (range) or Frequency (percentage)	Median (range) or Frequency (percentage)	P value
Age (years)	53.00 (17.00–85.00)	54.00 (18.00–85.00)	53.00 (17.00–77.00)	0.777
Female	172 (47.3%)	76 (41.8%)	96 (52.7%)
BMI (kg/m)	24.20 (14.90–47.80)	24.20 (16.70–33.50)	23.90 (14.90–47.80)	0.628
Weight (kg)	67.50 (40.00–130.00)	68.00 (46.50–110.00)	67.25 (40.00–130.00)	0.216
Height (m)	1.67 (1.46–1.88)	1.68 (1.50–1.85)	1.66 (1.46–1.88)	0.141
History of colonoscopy	189 (51.9%)	108 (59.3%)	81 (44.5%)
History of abdominal surgery	102 (28.0%)	50 (27.5%)	52 (28.6%)	0.815
Indications for colonoscopy
Abdominal pain/discomfort	116 (31.9%)	53 (29.1%)	63 (34.6%)	0.261
Bloating	22 (6.0%)	8 (4.4%)	14 (7.7%)	0.187
Abnormal defecation	261 (71.7%)	121 (66.5%)	140 (76.9%)
Polyp	59 (16.2%)	39 (21.4%)	20 (11.0%)
Health checkup	50 (13.7%)	31 (17.0%)	19 (10.4%)	0.068
Others	12 (3.3%)	6 (3.3%)	6 (3.3%)	1.000
Colonoscopy started in the morning	199 (54.7%)	156 (85.7%)	43 (23.6%)
Significant bubbles	6 (1.6%)	1 (0.5%)	5 (2.7%)	0.217
Adverse event
Nausea	23 (6.3%)	11 (6.0%)	12 (6.6%)	0.829
Vomiting	5 (1.4%)	2 (1.1%)	3 (1.6%)	1.000
Abdominal pain	1 (0.3%)	1 (0.3%)	0 (0%)	1.000
Bloating	3 (0.8%)	2 (1.1%)	1 (0.5%)	1.000
S-C – time interval between oral simethicone and the start of colonoscopy; BMI – body mass index.

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