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20 May 2024: Clinical Research

Effect of Individualized PEEP Guided by Driving Pressure on Diaphragm Function in Patients Undergoing Laparoscopic Radical Resection of Colorectal Cancer: A Randomized Controlled Trial

Mingyue Zhang ABCF* , Yongbo Yu BCD* , Cheng Qiu CE , Xiaoqiong Xia BCD* , Yuanming Sun E , Liang Wang DE , Guifen Ma BE , Xiang Gao E

DOI: 10.12659/MSM.944022

Med Sci Monit 2024; 30:e944022

Table 2 Comparison of secondary indicators between the 3 groups (mean±SD).

ParameterC group (n=30)F group (n=30)I group (n=30)FP value
Ppeakd013.7±1.113.5±1.613.4±1.60.2080.813
d118.2±1.521.0±2.3b 24.1±1.8,b 73.7380.000
d221.3±1.624.5±2.1b 27.2±1.9,b 78.4680.000
d321.5±1.524.2±1.9b 27.3±1.7,b 89.3710.000
d417.0±1.919.1±2.4b 23.7±1.8,b 82.1010.000
Pplatd010.8±1.210.6±1.310.2±1.22.0430.136
d114.0±1.317.4±2.1b 21.1±1.9,b 117.7770.000
d218.2±1.522.0±2.0b 25.1±1.8,b 116.1240.000
d319.7±1.622.1±2.0b 24.8±1.7,b 59.6470.000
d413.1±1.815.5±1.8b 20.4±1.7,b 137.5990.000
ΔPd010.8±1.210.6±1.310.3±1.31.5290.223
d114.0±1.312.4±2.1b 10.2±1.5,b 42.6940.000
d218.2±1.517.0±2.0b 14.2±1.2,b 49.2310.000
d319.7±1.617.1±2.0b 13.9±1.6,b 82.6240.000
d413.1±1.810.5±1.8b 9.5±1.8,b 31.0530.000
Cdynd031.4±4.030.9±4.430.6±3.60.2750.760
d123.5±3.125.0±3.626.5±3.0b 6.2860.003
d220.8±2.725.5±4.4b 29.2±4.9,b 30.7940.000
d320.7±2.825.9±5.0b 31.4±4.3,b 50.4440.000
d426.4±3.632.0±5.4b 37.0±3.9,b 44.2910.000
PaCO2d041.2±3.541.4±3.440.6±3.00.4030.670
d142.0±3.441.6±3.141.5±2.90.1870.830
d253.3±3.355.6±3.1b 60.1±3.0,b 36.0190.000
d355.5±3.357.6±3.2b 61.4±3.0,b 26.6600.000
d456.8±3.459.5±3.3b 62.4±2.7,b 23.6290.000
OId0415.5±23.2414.1±26.6412.9±22.40.0820.922
d1417.9±22.4416.9±26.5415.9±23.10.0480.953
d2417.1±23.4432.0±24.2b 452.4±18.7,b 18.9450.000
d3412.5±22.4424.6±19.5b 447.9±18.6,b 23.7100.000
d4402.7±20.4417.4±16.0b 435.8±21.3,b 21.9800.000
MAPd091.2±8.391.1±9.590.3±7.90.1010.904
d190±7.689.2±9.286.9±7.61.1630.317
d288.3±6.788.1±7.687.5±6.10.1190.888
d387.3±6.986.6±7.386.6±5.60.1230.885
d495.3±7.394.4±6.593.8±5.60.3890.679
HRd065.9±8.166.3±6.366.0±8.80.0210.979
d168.7±7.569.0±5.970.7±9.20.5520.578
d265.6±9.062.8±6.463.0±8.81.0740.346
d365.2±7.264.2±6.363.8±7.40.2950.745
d474.3±6.371.5±6.572.4±6.91.4520.240
Compared with C,
b
c
ΔP – driving pressure; Cdyn – dynamic compliance; HR – heart rate; MAP – mean arterial pressure; OI – oxygenation index; Ppeak – peak pressure; Pplat – plateau pressure.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750