14 June 2024 : Clinical Research
Perioperative Administration of Tranexamic Acid and Low Molecular Weight Heparin for Enhanced Blood Management in Intertrochanteric Fractures: A Randomized Controlled Study
Chunyong Zhu1AG*, Zhongqing Ji1ACE, Jiangfeng Zhu1CD, Hao Xu1AB, Shiyan Li1AB, Chuancheng Liu1CD, Bin Wei1DFDOI: 10.12659/MSM.944063
Med Sci Monit 2024; 30:e944063
Table 1 Baseline demographic and clinical characteristics.
| Variable | Total (n=79) | 4-dose TXA (n=22) | 1-dose TXA (n=25) | Control (n=32) | p value |
|---|---|---|---|---|---|
| Age (years) | 78.27±10.17 | 77.56±11.02 | 77.60±9.96 | 80.05±9.31 | 0.633 |
| Gender (n, %) | 0.081 | ||||
| Male | 33 (41.77) | 7 (31.82) | 15 (60.00) | 11 (34.38) | |
| Female | 46 (58.23) | 15 (68.18) | 10 (40.00) | 21 (65.62) | |
| BMI (kg/m) | 24.04±3.41 | 24.67±2.93 | 23.85±3.48 | 23.34±3.92 | 0.354 |
| AO fracture classification (n, %) | 0.976 | ||||
| 31A1 | 29 (36.71) | 8 (36.36) | 10 (40.00) | 11 (34.38) | |
| 31A2 | 39 (49.37) | 11 (50.00) | 11 (44.00) | 17 (53.12) | |
| 31A3 | 11 (13.92) | 3 (13.64) | 4 (16.00) | 4 (12.50) | |
| ASA grade (n, %) | 0.157 | ||||
| I | 7 (8.86) | 1 (4.55) | 2 (8.00) | 4 (12.50) | |
| II | 26 (32.91) | 3 (13.64) | 9 (36.00) | 14 (43.75) | |
| III | 43 (54.43) | 17 (77.27) | 13 (52.00) | 13 (40.62) | |
| IV | 3 (3.80) | 1 (4.55) | 1 (4.00) | 1 (3.12) | |
| Preoperative value | |||||
| Hct (%) | 33.06±4.83 | 33.58±5.69 | 31.51±3.94 | 33.73±4.55 | 0.207 |
| Hb (g/dl) | 111.43±16.74 | 112.40±19.54 | 106.18±14.13 | 114.28±15.67 | 0.206 |
| FG (g/L) | 2.95 (2.53, 3.73) | 3.06 (2.55, 3.69) | 2.84 (2.55, 3.97) | 2.96 (2.41, 3.63) | 0.924 |
| PT (sec) | 11.99 (11.30, 12.75) | 12.40 (11.76, 12.88) | 12.25 (11.52, 12.91) | 11.53 (11.11, 12.02) | 0.083 |
| APTT (sec) | 27.31 (24.80, 29.41) | 28.77 (24.95, 31.01) | 27.96 (26.35, 29.36) | 26.30 (24.33, 27.97) | 0.105 |
| D-dimer (μg/ml) | 7.85 (5.61, 10.18) | 8.32 (5.55, 12.33) | 7.91 (6.31, 9.09) | 7.07 (5.41, 10.17) | 0.696 |
| INR | 0.99 (0.94, 1.04) | 0.97 (0.92, 1.02) | 1.00 (0.96, 1.06) | 0.99 (0.95, 1.02) | 0.364 |
| TBV (ml) | 3627.89 (3262.81, 4241.60) | 3958.42 (3603.45, 4499.68) | 3657.29 (3298.92, 4100.91) | 3444.70 (3217.35, 4230.24) | 0.095 |
| Operation time (min) | 50.00 (40.00, 67.50) | 60.00 (45.00, 70.00) | 50.00 (40.00, 70.00) | 45.00 (40.00, 60.00) | 0.215 |
| Mean DVT diagnosed time (day) | 4.47±2.87 | 4.00±2.12 | 5.50±1.14 | 4.00±2.27 | 0.599 |
| Length of stay(day) | 9.76±4.62 | 9.13±3.98 | 10.80±5.61 | 9.37±4.16 | 0.394 |
| Descriptive statistics were presented as mean±standard deviation for continuous data and as frequencies (percentages) for categorical data. TXA – tranexamic acid; BMI – body mass index; ASA – American Society of Anesthesiologists; Hct – hematocrit; Hb – hemoglobin; FG – fibrinogen; PT – prothrombin time; APTT – activated partial thromboplastin time; INR – international normalized ratio; TBV – total blood volume; DVT – deep vein thrombosis. | |||||