14 June 2024 : Clinical Research
Perioperative Administration of Tranexamic Acid and Low Molecular Weight Heparin for Enhanced Blood Management in Intertrochanteric Fractures: A Randomized Controlled Study
Chunyong Zhu1AG*, Zhongqing Ji1ACE, Jiangfeng Zhu1CD, Hao Xu1AB, Shiyan Li1AB, Chuancheng Liu1CD, Bin Wei1DFDOI: 10.12659/MSM.944063
Med Sci Monit 2024; 30:e944063
Table 2 Primary outcomes of the study.
| Variable | Total (n=79) | 4-dose TXA (n=22) | 1-dose TXA (n=25) | Control (n=32) | p value |
|---|---|---|---|---|---|
| Hct drop | 7.35±3.11 | 5.26±1.99 | 7.04±2.99 | 9.03±2.94 | <0.001 |
| Hb drop | 23.39±11.40 | 15.64±8.63 | 20.76±8.89 | 30.78±10.53 | <0.001 |
| TBL | 982.70±501.79 | 640.86±337.22 | 971.74±511.14 | 1226.27±458.22 | <0.001 |
| HBL | 915.73±493.06 | 583.13±318.08 | 902.94±509.99 | 1154.39±452.06 | <0.001 |
| Transfusion rate (n, %) | 0.404 | ||||
| No | 60 (75.95) | 19 (86.36) | 18 (72.00) | 23 (71.88) | |
| Yes | 19 (24.05) | 3 (13.64) | 7 (28.00) | 9 (28.12) | |
| DVT accidence (n, %) | 0.982 | ||||
| No | 60 (75.95) | 17 (77.27) | 19 (76.00) | 24 (75.00) | |
| Yes | 19 (24.05) | 5 (22.73) | 6 (24.00) | 8 (25.00) | |
| TXA – tranexamic acid; Hct drop – hematocrit drop; Hb drop – hemoglobin drop; TBL – total blood loss; HBL – hidden blood loss; DVT – deep venous thrombosis. Lowercase letters indicate multiple comparison result markers, with the same letter indicating p>0.05. | |||||