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22 May 2024: Clinical Research

Incidence, Risk Factors, and Outcomes of Left Atrial Enlargement in Patients Requiring Right Ventricular Pacing: A Retrospective Study of 461 Cases from 2012 to 2020

Wei-Chieh Lee 123ABCDEF , Wei-Ting Chang 123CD , Hsiu-Yu Fang 45B , Huang-Chung Chen 4B , Mien-Cheng Chen 4EF* , Ping-Yen Liu 16EF*

DOI: 10.12659/MSM.944114

Med Sci Monit 2024; 30:e944114

Table 3 Univariate and multivariate logistic regression analyses of predictors of significant LAE.

VariablesUnivariate analysisMultivariate analysis
OR95% CIP valueOR95% CIP value
Male0.8160.519–1.2810.377
Age (per 10 years)0.9410.793–1.1160.486
BMI0.9900.959–1.0230.562
Hypertension1.0730.648–1.7760.785
Diabetes mellitus0.7660.476–1.2350.275
Hyperlipidemia0.5010.261–0.9630.0380.6610.245–1.7790.412
Coronary artery disease0.8030.429–1.5040.493
End stage renal disease1.0590.383–2.9300.912
Prior stroke or TIA1.2840.683–2.4150.438
Pre-implant LA0.7920.746–0.8400.7760.728–0.828
Pre-implant LVEF0.9950.970–1.0210.714
Pre-implant LVEDV0.9910.983–0.9990.0210.9970.985–1.0100.676
Pre-implant LVESV0.9820.964–1.0010.0600.9920.963–1.0210.580
Post-implant LVEF0.9810.965–1.0070.0230.9760.957–0.9950.014
PICM1.2600.739–2.1500.396
Post-implant LVEDV0.9970.993–1.0040.620
Post-implant LVESV1.0010.994–1.0070.773
Post-implant development of moderate to severe MR2.5591.413–4.6340.0022.3571.172–4.7400.016
Pacing QRS duration0.9940.979–1.0080.375
Lead position at lower septum and apex1.3380.760–2.3540.313
Pacing years (per year)1.0881.030–1.1490.003
≥3.3 years1.6941.068–2.6870.0251.5761.039–2.6460.045
New-onset atrial fibrillation after implantation1.4840.913–2.4110.1111.0890.489–2.4260.835
ACEI/ARB0.9850.590–1.6450.954
β-blocker0.8120.425–1.5520.529
Statin0.6510.388–1.0930.1040.8960.401–2.0020.788
OR – odds ratio; CI – confidence interval; BMI – body mass index; TIA – transient ischemic attack; LA – left atrium; LAE – left atrial enlargement; LVEF – left ventricular ejection fraction; LVEDV – left ventricular end-diastolic volume; LVESV – left ventricular end-systolic volume; LVEF – left ventricular ejection fraction; PICM – pacing-induced cardiomyopathy; MR – mitral regurgitation; ACEI – angiotensin-converting-enzyme inhibitor; ARB – angiotensin II receptor blocker.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750