Incidence, Risk Factors, and Outcomes of Left Atrial Enlargement in Patients Requiring Right Ventricular Pacing: A Retrospective Study of 461 Cases from 2012 to 2020

Wei-Chieh Lee; Wei-Ting Chang; Hsiu-Yu Fang; Huang-Chung Chen; Mien-Cheng Chen; Ping-Yen Liu

doi:10.12659/MSM.944114

22 May 2024 : Clinical Research

Incidence, Risk Factors, and Outcomes of Left Atrial Enlargement in Patients Requiring Right Ventricular Pacing: A Retrospective Study of 461 Cases from 2012 to 2020

Wei-Chieh Lee

^123ABCDEF*, Wei-Ting Chang^123CD, Hsiu-Yu Fang^45B, Huang-Chung Chen

^4B, Mien-Cheng Chen^4EF, Ping-Yen Liu^16EF

DOI: 10.12659/MSM.944114

Med Sci Monit 2024; 30:e944114

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Table 3 Univariate and multivariate logistic regression analyses of predictors of significant LAE.

Variables	Univariate analysis			Multivariate analysis
Variables	OR	95% CI	P value	OR	95% CI	P value
Male	0.816	0.519–1.281	0.377
Age (per 10 years)	0.941	0.793–1.116	0.486
BMI	0.990	0.959–1.023	0.562
Hypertension	1.073	0.648–1.776	0.785
Diabetes mellitus	0.766	0.476–1.235	0.275
Hyperlipidemia	0.501	0.261–0.963	0.038	0.661	0.245–1.779	0.412
Coronary artery disease	0.803	0.429–1.504	0.493
End stage renal disease	1.059	0.383–2.930	0.912
Prior stroke or TIA	1.284	0.683–2.415	0.438
Pre-implant LA	0.792	0.746–0.840	<0.001	0.776	0.728–0.828	<0.001
Pre-implant LVEF	0.995	0.970–1.021	0.714
Pre-implant LVEDV	0.991	0.983–0.999	0.021	0.997	0.985–1.010	0.676
Pre-implant LVESV	0.982	0.964–1.001	0.060	0.992	0.963–1.021	0.580
Post-implant LVEF	0.981	0.965–1.007	0.023	0.976	0.957–0.995	0.014
PICM	1.260	0.739–2.150	0.396
Post-implant LVEDV	0.997	0.993–1.004	0.620
Post-implant LVESV	1.001	0.994–1.007	0.773
Post-implant development of moderate to severe MR	2.559	1.413–4.634	0.002	2.357	1.172–4.740	0.016
Pacing QRS duration	0.994	0.979–1.008	0.375
Lead position at lower septum and apex	1.338	0.760–2.354	0.313
Pacing years (per year)	1.088	1.030–1.149	0.003
≥3.3 years	1.694	1.068–2.687	0.025	1.576	1.039–2.646	0.045
New-onset atrial fibrillation after implantation	1.484	0.913–2.411	0.111	1.089	0.489–2.426	0.835
ACEI/ARB	0.985	0.590–1.645	0.954
β-blocker	0.812	0.425–1.552	0.529
Statin	0.651	0.388–1.093	0.104	0.896	0.401–2.002	0.788
OR – odds ratio; CI – confidence interval; BMI – body mass index; TIA – transient ischemic attack; LA – left atrium; LAE – left atrial enlargement; LVEF – left ventricular ejection fraction; LVEDV – left ventricular end-diastolic volume; LVESV – left ventricular end-systolic volume; LVEF – left ventricular ejection fraction; PICM – pacing-induced cardiomyopathy; MR – mitral regurgitation; ACEI – angiotensin-converting-enzyme inhibitor; ARB – angiotensin II receptor blocker.

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Incidence, Risk Factors, and Outcomes of Left Atrial Enlargement in Patients Requiring Right Ventricular Pacing: A Retrospective Study of 461 Cases from 2012 to 2020

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