01 June 2024 : Clinical Research
Comparison of Fentanyl, Ketamine, and Lidocaine Combined with Propofol Anesthesia in Patients with Crohn Disease Undergoing Colonoscopy
Kamil Chudziński
1ABCDEF, Konstanty Szułdrzyński 1DEF, Miłosz Jankowski 1CDEF, Kamil Adamczyk 1EF*, Elżbieta Sokół-Kobielska2DEF
DOI: 10.12659/MSM.944116
Med Sci Monit 2024; 30:e944116
Table 1 Comparison of demographic and clinical characteristics among patients undergoing fentanyl, ketamine, and lidocaine anesthesia.
| Variable | Fentanyl (n=47) | Ketamine (n=47) | Lidocaine (n=52) | P |
|---|---|---|---|---|
| Age, years, median (IQR) | 49 (33–60) | 37 (28.5–47.5) | 39.5 (30–56) | 0.0502 |
| Sex (Male/Female), n (%) | 20 (40.8%)/27 (59.2%) | 22 (46.8%)/25 (53.2%) | 31(59.6%)/21 (40.4%) | 0.2063 |
| BMI, kg/m, mean (SD) | 23.53 (4.31) | 24.67 (4.08) | 25.04 (5.07) | 0.142 |
| Colonoscopy duration, min, mean (SD) | 14.83 (6.05) | 15.81 (7.01) | 15.12 (7.97) | 0.7595 |
| Total propofol dose, mg, mean (SD) | 136.81 (61.44) | 108.3 (42.6) | 118.85 (44.44) | |
| Total propofol dose, mg/kg BW/min mean (SD) | 0.14 (0.05) | 0.1 (0.04) | 0.12 (0.04) | |
| Desaturation, n (%) | 20 (42.6%) | 3 (6.4%) | 4 (7.7%) | |
| Desaturation in first 5 minutes of anesthesia, n (%) | 12 (25.5%) | 2 (4.3%) | 4 (7.7%) | |
| Severe desaturation, n (%) | 2 (4.3%) | 0 | 0 | 0.2043 |
| MAP below 65 mmHg, n (%) | 7 (14.9%) | 5 (10.6%) | 10 (19.2%) | 0.4776 |
| MAP below 55 mmHg, n (%) | 2 (4.3%) | 1 (2.1%) | 2 (3.8%) | 1 |
| ΔMAP, mmHg, mean (SD) | −9.89 (9.19) | −5.47 (13.08) | −6.71 (10.07) | |
| ΔSBP, mmHg, mean (SD) | −16.74 (10.87) | −7.19 (11.46) | −13.19 (14.96) | |
| ΔDBP, mmHg, mean (SD) | −6.36 (10.13) | −4.62 (16.59) | −3.56 (10.44) | 0.2203 |
| Short-term Awakening, n (%) | 8 (17.4%) | 7 (15.2%) | 12 (23.1%) | 0.5852 |
| Post-anesthesia adverse events, n (%) | 13 (27.7%) | 16 (34%) | 14 (26.9%) | 0.7014 |
| Time to regain consciousness after procedure, s, mean (SD) | 65.06 (63.57) | 33.83 (62.23) | 18.46 (19.74) | |
| Aldrete Score, points, mean (SD) | 9.49 (0.62) | 9.77 (0.43) | 9.81 (0.4) | |
| PADSS, points, mean (SD) | 8.68 (0.75) | 9.19 (0.92) | 9.29 (0.8) | |
| Satisfaction with anesthesia in NRS scale, points, median (IQR) | 10 (10–10) | 10 (10–10) | 10 (10–10) | 0.797 |
| Abdominal pain after procedure, n (%) | 15 (31.9%) | 13 (27.7%) | 14 (26.9%) | 0.843 |
| Pain Intensity in group reporting pain in NRS scale, points, median (IQR) | 3 (1.5–5) | 4 (2–7) | 4.5 (1.25–5.75) | 0.7771 |
| BW – body weight; BMI – body mass index; MAP – mean arterial pressure; ΔMAP/ΔSBP/ΔDBP – changes in individual mean, systolic, diastolic blood pressure values compared with baseline; NRS – numerical rating scale, range from 1 to 10 points; PADDS – Post Anesthetic Discharge Scoring System; SD – standard deviation; IQR – interquartile range. | ||||