Lipid Peroxidation, Reduced Glutathione, and Glutathione Peroxidase Levels in Intervertebral Discs of Patients with Lumbar Degenerative Disc Disease

Noppawan Phumala Morales; Witcharat Loahachanwanich; Ekkapoj Korwutthikulrangsri; Monchai Ruangchainikom; Werasak Sutipornpalangkul

doi:10.12659/MSM.944335

24 May 2024 : Clinical Research

Lipid Peroxidation, Reduced Glutathione, and Glutathione Peroxidase Levels in Intervertebral Discs of Patients with Lumbar Degenerative Disc Disease

Noppawan Phumala Morales^1ACEF, Witcharat Loahachanwanich^2B, Ekkapoj Korwutthikulrangsri^2AE, Monchai Ruangchainikom^2AE, Werasak Sutipornpalangkul^2ABDEF*

DOI: 10.12659/MSM.944335

Med Sci Monit 2024; 30:e944335

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Table 1 Demographic and clinical characteristics of the study population.

Characteristics	LDD (n=32)	NonLDD (n=10)	P
n (%)			0.127
Male	9 (28)	6 (60)
Female	23 (72)	4 (40)
years	60.63±10.89	31.70±6.36	<0.001^*
kg/m	27.19±5.39	24.08±3.31	0.089
n (%)
HNP	8 (25)	10 (100)
Spinal stenosis	14 (44)	0
Spondylolisthesis	8 (25)	0
DDD	2 (6)	0
n (%)
Grade II	0	10 (100)
Grade III	12 (38)	0
Grade IV	10 (31)	0
Grade V	10 (31)	0
n (%)
None	8 (25)	10 (100)
HT	18 (56)	0
DLP	12 (37)	0
^* Significant at a value of less than 0.05. Statistical analyses by Mann-Whitney U test, chi-square test, and Fisher’s exact test. LDD – lumbar disc degeneration; NonLDD – nonlumbar disc degeneration; BMI – body mass index; HNP – herniated nucleus pulposus; DDD – degenerative disc disease; HT – hypertension; DLP – dyslipidemia.

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Lipid Peroxidation, Reduced Glutathione, and Glutathione Peroxidase Levels in Intervertebral Discs of Patients with Lumbar Degenerative Disc Disease

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