Lipid Peroxidation, Reduced Glutathione, and Glutathione Peroxidase Levels in Intervertebral Discs of Patients with Lumbar Degenerative Disc Disease

Noppawan Phumala Morales; Witcharat Loahachanwanich; Ekkapoj Korwutthikulrangsri; Monchai Ruangchainikom; Werasak Sutipornpalangkul

doi:10.12659/MSM.944335

24 May 2024 : Clinical Research

Lipid Peroxidation, Reduced Glutathione, and Glutathione Peroxidase Levels in Intervertebral Discs of Patients with Lumbar Degenerative Disc Disease

Noppawan Phumala Morales^1ACEF, Witcharat Loahachanwanich^2B, Ekkapoj Korwutthikulrangsri^2AE, Monchai Ruangchainikom^2AE, Werasak Sutipornpalangkul^2ABDEF*

DOI: 10.12659/MSM.944335

Med Sci Monit 2024; 30:e944335

Authors information Article notes Copyright and License information

Introduction Material and Methods Results Discussion Conclusions References

Related articles Order reprints Share article Share by email

View HTML version

Table 2 Comparative analysis of thiobarbituric acid reactive substances, reduced glutathione, and glutathione peroxidase levels in excised lumbar intervertebral discs of LDD and non LDD patients.

Parameters	LDD (n=32)	NonLDD (n=10)	P
(nmol/g)	5.18±4.14	2.56±1.23	0.008^*
(nmol/mg protein)	0.39±0.26	0.38±0.38	0.708
(μmol NADPH/min per mg protein)	69.69±34.22	58.81±36.97	0.299
^* Significant at a value of less than 0.05. Statistical analyses by Mann-Whitney U test. LDD – lumbar disc degeneration; NonLDD – nonlumbar disc degeneration; TBARs – thiobarbituric acid reactive substances; GSH – reduced glutathione; GPx – glutathione peroxidase; NADPH – nicotinamide adenine dinucleotide phosphate.

Back to the Article

Lipid Peroxidation, Reduced Glutathione, and Glutathione Peroxidase Levels in Intervertebral Discs of Patients with Lumbar Degenerative Disc Disease

Your Privacy