05 June 2024 : Clinical Research
Serum Lipoprotein(a) Levels as a Predictor of Aortic Stiffness in Patients on Long-Term Peritoneal Dialysis
Po-Yu Huang
12BCDEF, Bang-Gee Hsu345ABCDEFG, Yu-Li Lin345ABCG, Chi-Chong Tang34B, Hung-Hsiang Liou6AD, Jen-Pi Tsai135ABCDFG*
DOI: 10.12659/MSM.944348
Med Sci Monit 2024; 30:e944348
Table 1 The clinical variable of the 148 peritoneal dialysis patients with or without arterial stiffness.
| Characteristic | All participants (n=148) | Control group (n=116) | Arterial stiffness group (n=32) | P value |
|---|---|---|---|---|
| Age (years) | 58.61±12.71 | 57.42±13.19 | 62.94±9.78 | 0.029* |
| Peritoneal dialysis vintage (months) | 48.54 (21.03–81.42) | 45.66 (19.71–89.91) | 49.70 (25.41–91.65) | 0.502 |
| Height (cm) | 160.00 (156.00–168.00) | 160.00 (156.00–168.00) | 160.00 (157.00–168.00) | 0.796 |
| Body weight (kg) | 65.38±11.00 | 64.93±10.84 | 67.01±11.62 | 0.346 |
| Body mass index (kg/m2) | 24.88±3.29 | 24.72±3.26 | 25.49±3.38 | 0.244 |
| Waist circumference (cm) | 93.16±10.84 | 91.95±11.21 | 97.56±8.09 | 0.009* |
| Carotid-femoral PWV (m/s) | 9.23±1.57 | 8.61±1.00 | 11.47±1.15 | <0.001* |
| Systolic blood pressure (mmHg) | 147.00±22.18 | 140.05±22.70 | 154.06±18.87 | 0.041* |
| Diastolic blood pressure (mmHg) | 84.05±15.32 | 83.89±15.51 | 84.66±14.86 | 0.803 |
| Hemoglobin (g/dL) | 9.61±1.52 | 9.57±1.38 | 9.78±1.95 | 0.480 |
| Total cholesterol (mg/dL) | 161.97±49.99 | 159.16±45.72 | 172.16±62.93 | 0.194 |
| Triglyceride (mg/dL) | 130.50 (83.00–201.25) | 127.00 (77.25–197.00) | 148.50 (106.50–227.75) | 0.062 |
| Fasting glucose (mg/dL) | 103.00 (93.00–128.75) | 100.50 (92.00–123.00) | 121.00 (95.25–166.25) | 0.014* |
| Albumin (mg/dL) | 3.56±0.35 | 3.57±0.36 | 3.51±0.33 | 0.354 |
| Blood urea nitrogen (mg/dL) | 64.90±21.79 | 63.37±21.27 | 70.44±23.08 | 0.105 |
| Creatinine (mg/dL) | 10.80±2.94 | 10.67±3.02 | 11.30±2.60 | 0.287 |
| Total calcium (mg/dL) | 9.64±0.78 | 9.59±0.78 | 9.83±0.75 | 0.117 |
| Phosphorus (mg/dL) | 5.23±1.38 | 5.27±1.41 | 5.09±1.30 | 0.513 |
| Intact parathyroid hormone (pg/mL) | 227.67 (89.43–429.79) | 222.67 (84.33–415.62) | 232.21 (95.88–545.62) | 0.592 |
| Lipoprotein(a) (mg/L) | 120.43 (78.85–199.44) | 103.42 (61.04–175.68) | 221.40 (120.66–302.73) | <0.001* |
| Weekly Kt/V | 2.06±0.48 | 2.10±0.51 | 1.91±0.32 | 0.045* |
| Peritoneal Kt/V | 1.87±0.49 | 1.90±0.51 | 1.76±0.40 | 0.145 |
| Total clearance of creatinine (L/week) | 2.01 (1.75–2.30) | 2.04 (1.77–2.36) | 1.94 (1.71–2.07) | 0.075 |
| Peritoneal clearance of creatinine (L/week) | 47.57±13.05 | 46.89±12.87 | 50.04±13.63 | 0.228 |
| Female, n (%) | 82 (55.4) | 67 (57.8) | 15 (46.9) | 0.277 |
| Diabetes, n (%) | 59 (39.9) | 39 (33.6) | 20 (62.5) | 0.003* |
| Hypertension, n (%) | 107 (72.3) | 82 (70.7) | 25 (78.1) | 0.405 |
| CAPD, n (%) | 87 (58.8) | 68 (58.6) | 19 (59.4) | 0.939 |
| ARB use, n (%) | 93 (62.8) | 74 (63.8) | 19 (59.4) | 0.647 |
| β-blocker use, n (%) | 72 (48.6) | 55 (47.4) | 17 (53.1) | 0.567 |
| CCB use, n (%) | 91 (61.5) | 72 (62.1) | 19 (59.4) | 0.782 |
| Statin use, n (%) | 41 (27.7) | 33 (28.4) | 8 (25.0) | 0.700 |
| Values for continuous variables are shown as mean±standard deviation after analysis by Student’s -test; variables not normally distributed are shown as median and interquartile range after examination by the Mann-Whitney U test; values are presented as number (%) and analysis after analysis by the chi-square test. PWV – pulse wave velocity; CAPD – continuous ambulatory peritoneal dialysis; Weekly Kt/V – weekly fractional clearance index for urea; ARB – angiotensin-receptor blocker; CCB – calcium-channel blocker. * | ||||