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05 June 2024 : Clinical Research  

Serum Lipoprotein(a) Levels as a Predictor of Aortic Stiffness in Patients on Long-Term Peritoneal Dialysis

Po-Yu Huang ORCID logo12BCDEF, Bang-Gee Hsu345ABCDEFG, Yu-Li Lin345ABCG, Chi-Chong Tang34B, Hung-Hsiang Liou6AD, Jen-Pi Tsai135ABCDFG*

DOI: 10.12659/MSM.944348

Med Sci Monit 2024; 30:e944348

Table 1 The clinical variable of the 148 peritoneal dialysis patients with or without arterial stiffness.

CharacteristicAll participants (n=148)Control group (n=116)Arterial stiffness group (n=32)P value
Age (years)58.61±12.7157.42±13.1962.94±9.780.029*
Peritoneal dialysis vintage (months)48.54 (21.03–81.42)45.66 (19.71–89.91)49.70 (25.41–91.65)0.502
Height (cm)160.00 (156.00–168.00)160.00 (156.00–168.00)160.00 (157.00–168.00)0.796
Body weight (kg)65.38±11.0064.93±10.8467.01±11.620.346
Body mass index (kg/m2)24.88±3.2924.72±3.2625.49±3.380.244
Waist circumference (cm)93.16±10.8491.95±11.2197.56±8.090.009*
Carotid-femoral PWV (m/s)9.23±1.578.61±1.0011.47±1.15*
Systolic blood pressure (mmHg)147.00±22.18140.05±22.70154.06±18.870.041*
Diastolic blood pressure (mmHg)84.05±15.3283.89±15.5184.66±14.860.803
Hemoglobin (g/dL)9.61±1.529.57±1.389.78±1.950.480
Total cholesterol (mg/dL)161.97±49.99159.16±45.72172.16±62.930.194
Triglyceride (mg/dL)130.50 (83.00–201.25)127.00 (77.25–197.00)148.50 (106.50–227.75)0.062
Fasting glucose (mg/dL)103.00 (93.00–128.75)100.50 (92.00–123.00)121.00 (95.25–166.25)0.014*
Albumin (mg/dL)3.56±0.353.57±0.363.51±0.330.354
Blood urea nitrogen (mg/dL)64.90±21.7963.37±21.2770.44±23.080.105
Creatinine (mg/dL)10.80±2.9410.67±3.0211.30±2.600.287
Total calcium (mg/dL)9.64±0.789.59±0.789.83±0.750.117
Phosphorus (mg/dL)5.23±1.385.27±1.415.09±1.300.513
Intact parathyroid hormone (pg/mL)227.67 (89.43–429.79)222.67 (84.33–415.62)232.21 (95.88–545.62)0.592
Lipoprotein(a) (mg/L)120.43 (78.85–199.44)103.42 (61.04–175.68)221.40 (120.66–302.73)*
Weekly Kt/V2.06±0.482.10±0.511.91±0.320.045*
Peritoneal Kt/V1.87±0.491.90±0.511.76±0.400.145
Total clearance of creatinine (L/week)2.01 (1.75–2.30)2.04 (1.77–2.36)1.94 (1.71–2.07)0.075
Peritoneal clearance of creatinine (L/week)47.57±13.0546.89±12.8750.04±13.630.228
Female, n (%)82 (55.4)67 (57.8)15 (46.9)0.277
Diabetes, n (%)59 (39.9)39 (33.6)20 (62.5)0.003*
Hypertension, n (%)107 (72.3)82 (70.7)25 (78.1)0.405
CAPD, n (%)87 (58.8)68 (58.6)19 (59.4)0.939
ARB use, n (%)93 (62.8)74 (63.8)19 (59.4)0.647
β-blocker use, n (%)72 (48.6)55 (47.4)17 (53.1)0.567
CCB use, n (%)91 (61.5)72 (62.1)19 (59.4)0.782
Statin use, n (%)41 (27.7)33 (28.4)8 (25.0)0.700
Values for continuous variables are shown as mean±standard deviation after analysis by Student’s -test; variables not normally distributed are shown as median and interquartile range after examination by the Mann-Whitney U test; values are presented as number (%) and analysis after analysis by the chi-square test. PWV – pulse wave velocity; CAPD – continuous ambulatory peritoneal dialysis; Weekly Kt/V – weekly fractional clearance index for urea; ARB – angiotensin-receptor blocker; CCB – calcium-channel blocker.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750