05 June 2024 : Clinical Research
Serum Lipoprotein(a) Levels as a Predictor of Aortic Stiffness in Patients on Long-Term Peritoneal Dialysis
Po-Yu Huang
12BCDEF, Bang-Gee Hsu345ABCDEFG, Yu-Li Lin345ABCG, Chi-Chong Tang34B, Hung-Hsiang Liou6AD, Jen-Pi Tsai135ABCDFG*
DOI: 10.12659/MSM.944348
Med Sci Monit 2024; 30:e944348
Table 3 Correlation between carotid–femoral pulse wave velocity levels and clinical variables among 148 peritoneal dialysis patients.
| Variables | Carotid-femoral PWV (m/s) | ||||
|---|---|---|---|---|---|
| Simple regression | Multivariable regression | ||||
| r | P value | Beta | Adjusted R2 | P value | |
| Female | −0.063 | 0.447 | – | – | – |
| Diabetes | 0.404 | <0.001* | 0.317 | 0.158 | <0.001* |
| Hypertension | 0.068 | 0.413 | – | – | – |
| Age (years) | 0.295 | <0.001* | 0.198 | 0.028 | 0.003* |
| Log-PD vintage (months) | −0.019 | 0.822 | – | – | – |
| Body mass index (kg/m) | 0.141 | 0.087 | – | – | – |
| Waist circumference (cm) | 0.306 | <0.001* | 0.178 | 0.025 | 0.008* |
| Systolic blood pressure (mmHg) | 0.281 | 0.001* | 0.174 | 0.024 | 0.010* |
| Diastolic blood pressure (mmHg) | 0.083 | 0.318 | – | – | – |
| Hemoglobin (g/dL) | 0.122 | 0.141 | |||
| Total cholesterol (mg/dl) | 0.216 | 0.008* | – | – | – |
| Log-Triglyceride (mg/dL) | 0.156 | 0.059 | – | – | – |
| Log-Glucose (mg/dL) | 0.322 | <0.001* | – | – | – |
| Albumin (mg/dL) | −0.069 | 0.402 | – | – | – |
| Blood urea nitrogen (mg/dL) | 0.053 | 0.520 | – | – | – |
| Creatinine (mg/dL) | 0.068 | 0.408 | – | – | – |
| Total calcium (mg/dL) | 0.158 | 0.056 | – | – | – |
| Phosphorus (mg/dL) | −0.084 | 0.312 | – | – | – |
| Log-iPTH (pg/mL) | −0.060 | 0.472 | – | – | – |
| Log-Lipoprotein(a) (mg/L) | 0.396 | <0.001* | 0.342 | 0.170 | <0.001* |
| Weekly Kt/V | 0.069 | 0.515 | – | – | – |
| Peritoneal Kt/V | 0.050 | 0.635 | – | – | – |
| Log-Total clearance of creatinine (L/week) | −0.004 | 0.973 | – | – | – |
| Peritoneal clearance of creatinine (L/week) | −0.013 | 0.905 | – | – | – |
| Data of PD vintage, triglyceride, glucose, iPTH, total clearance of creatinine, and lipoprotein(a) levels showed skewed distribution and therefore were log-transformed before analysis. Analysis data was done using simple regression analyses or multivariate stepwise linear regression analysis (adopted factors: diabetes, age, waist circumference, systolic blood pressure, total cholesterol, log-glucose, and log-lipoprotein(a)). PD – peritoneal dialysis; iPTH – intact parathyroid hormone; Weekly Kt/V – weekly fractional clearance index for urea. * | |||||