27 June 2024 : Clinical Research
Elevated Plasma Levels of Growth Arrest Specific 6 (Gas6) Protein in Severe Obesity: Implications for Adipose Tissue and Inflammation
Daniele Sola1CDEFG*, Mattia Bellan1ABCDEF, Stefania Mai2ABCDE, Rosalba Minisini3CD, Mattia Perazzi4E, Amelia Brunani2ABCD, Sergio Gentilli5E, Pier Paolo Sainaghi1E, Massimo Scacchi6ABCD, Paolo Marzullo1ABCDFDOI: 10.12659/MSM.944462
Med Sci Monit 2024; 30:e944462
Table 1 General features of the study population.
| Patients with obesityN=42 | ControlsN=32 | p | |
|---|---|---|---|
| Age (years) | 38.0 [25.5–47.5] | 58.0 [46.0–69.0] | 0.0001 |
| Gender (M/F) | 17/25 | 18/14 | ns |
| BMI (kg/m) | 43.8 [41.5–55.7] | 25.3 [23.0–26.06] | |
| AST (U/L) | 19.5 [15.0–23.0] | 19.0 [16.0–23.0] | 0.94 |
| ALT (U/L) | 23.5 [18.0–33.5] | 21.0 [16.0–27.0] | 0.25 |
| GGT (U/L) | 20.0 [16.0–31.5] | 26.5 [17.5–45.5] | 0.16 |
| t-CHO (mg/dL) | 171.0 [148.5–200.0] | 187.5 [170.5–209.0] | 0.19 |
| HDL-CHO (mg/dL) | 47.0 [38.0–53.5] | 42.0 [34.0–56.5] | 0.63 |
| LDL-CHO (mg/dL) | 110.5 [92.5–138.0] | 117.0 [96.5–140.3] | 0.64 |
| TG (mg/dL) | 104.0 [84.0–141.0] | 91.0 [69.5–135.5] | 0.26 |
| Gas 6 (ng/mL) | 27.2 [23.8–31.1] | 22.3 [17.5–27.5] | |
| Leptin (ng/mL) | 48.3 [39.1–64.4] | 6.1 [2.8–12.0] | |
| Adiponectin (μg/mL) | 7.3 [5.6–10.2] | 8.3 [5.9–11.1] | 0.35 |
| FPG (mg/dL) | 101.5 [90.5–107.5] | 88.0 [83.5–95.0] | |
| FPI (mU/L) | 16.2 [11.5–23.4] | 6.5 [3.2–10.7] | |
| HOMA-IR | 3.8 [2.3–5.5] | 1.93 [0.81–2.83] | |
| The table reports the general features of the study population. In the left column the values are reported (with the interquartile ranges in square brackets) referring to patients with obesity, in the central column those referring to normal weight controls, in the right column the values (statistically significant values are shown in bold). Gas6 – growth arrest-specific 6; BMI – body mass index; AST – aspartate aminotransferase; ALT – alanine aminotransferase; GGT – gamma glutamyl-transferase; t-CHO – total cholesterol; HDL-CHO – high density lipoprotein; LDL-CHO – low density lipoprotein; TG – triglycerides; FPG – fasting plasma glucose; 2h-PG – plasma glucose 2 h after glucose load; FPI – fasting plasma insulin; 2h-PI – plasma insulin 2 h after glucose load; HOMA-IR – homeostatic model assessment for insulin resistance; HbA1c – glycated haemoglobin. | |||