27 June 2024 : Clinical Research
Elevated Plasma Levels of Growth Arrest Specific 6 (Gas6) Protein in Severe Obesity: Implications for Adipose Tissue and Inflammation
Daniele Sola1CDEFG*, Mattia Bellan1ABCDEF, Stefania Mai2ABCDE, Rosalba Minisini3CD, Mattia Perazzi4E, Amelia Brunani2ABCD, Sergio Gentilli5E, Pier Paolo Sainaghi1E, Massimo Scacchi6ABCD, Paolo Marzullo1ABCDFDOI: 10.12659/MSM.944462
Med Sci Monit 2024; 30:e944462
Table 3 Correlation between growth arrest-specific 6 (Gas6) levels and glucose metabolism indices stratified by sex.
| Variable | General populationN=42 | FemalesN=25 | MalesN=17 |
|---|---|---|---|
| HbA1c | (ρ=0.024; p=0.93) | ||
| FPG | (ρ=0.021; p=0.90) | (ρ=−0.003; p=0.99) | (ρ=0.108; p=0.69) |
| 2hPG | (ρ=0.192; p=0.24) | (ρ=0.315; p=0.13) | (ρ=−0.056; p=0.84) |
| FPI | (ρ=−0.052; p=0.75) | (ρ=−0.146; p=0.50) | (ρ=−0.029; p=0.91) |
| 2hPI | (ρ=−0.260; p=0.11) | (ρ=−0.176; p=0.41) | (ρ=−0.321; p=0.23) |
| HOMA-IR | (ρ=−0.037; p=0.82) | (ρ=−0.123; p=0.57) | (ρ=0.029; p=0.91) |
| DI | (ρ=−0.301; p=0.07) | (ρ=−0.187; p=0.52) | |
| ISI | (ρ=0.073; p=0.67) | (ρ=0.067; p=0.76) | (ρ=0.121; p=0.68) |
| IGI | (ρ=−0.262; p=0.37) | ||
| The table illustrates the association between Gas6 levels and indices/parameters of glucose metabolism. In the left column, data relating to female patients are presented, while in the right column, data relating to male patients are presented. Gas6 – growth arrest-specific 6; HbA1c – glycosylated haemoglobin; FPG – fasting plasma glucose; 2hPG – 2-h plasma glucose; FPI – fasting plasma insulin; 2hPI – 2-h plasma insulin; HOMA-IR – homeostatic model assessment for resistance to insulin; DI – disposition index; ISI – insulin sensitivity index; IGI – insulinogenic index. | |||