05 August 2024 : Clinical Research
Preoperative Thyroid-Stimulating Hormone Levels and Three-Year Mortality in Elderly Hip Fracture Patients: Insights from a Prospective Cohort Study
Yimin Chen

DOI: 10.12659/MSM.944465
Med Sci Monit 2024; 30:e944465
Table 2 Unadjusted and adjusted association between admission TSH and 3-year mortality.
TSH (mIU/L) | Events, n (%) | Unadjusted | Model 1* | Model 2** | ||||
---|---|---|---|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |||
Continuous | Per 1 | 153 (20.6) | 0.97 (0.90–1.04) | 0.346 | 0.98 (0.92–1.05) | 0.630 | 0.98 (0.92–1.05) | 0.639 |
Dichotomy | <1.64 | 85 (22.7) | 1 (Reference) | 1 (Reference) | 1 (Reference) | |||
≥1.64 | 68 (18.5) | 0.79 (0.58–1.09) | 0.157 | 0.88 (0.64–1.22) | 0.448 | 0.86 (0.62–1.20) | 0.379 | |
Quartile | Q1 (<0.98) | 42 (22.0) | 1 (Reference) | 1 (Reference) | 1 (Reference) | |||
Q2 (0.98–1.64) | 43 (23.5) | 1.1 (0.72–1.69) | 0.650 | 1.14 (0.75–1.76) | 0.536 | 1.13 (0.73–1.74) | 0.575 | |
Q3 (1.64–2.86) | 37 (19.9) | 0.9 (0.58–1.40) | 0.639 | 0.96 (0.62–1.50) | 0.867 | 0.93 (0.6–1.46) | 0.768 | |
Q4 (≥2.86) | 31 (17.1) | 0.77 (0.48–1.22) | 0.262 | 0.92 (0.58–1.47) | 0.727 | 0.9 (0.56–1.44) | 0.664 | |
Thyroid function status# | Normal (0.27–4.20) | 128 (20.6) | 1 (Reference) | 1 (Reference) | 1 (Reference) | |||
Hypo## | 11 (33.3) | 1.67 (0.90–3.09) | 0.103 | 1.38 (0.74–2.56) | 0.311 | 1.34 (0.72–2.49) | 0.359 | |
Subclinical-hypo### | 8 (11.8) | 0.54 (0.27–1.11) | 0.095 | 0.76 (0.37–1.56) | 0.452 | 0.77 (0.38–1.60) | 0.489 | |
Hyper@ | 1 (16.7) | 0.72 (0.10–5.15) | 0.743 | 1.07 (0.15–7.67) | 0.949 | 1.15 (0.16–8.30) | 0.890 | |
Subclinical-hyper@@ | 3 (33.3) | 1.59 (0.51–4.99) | 0.428 | 1.19 (0.38–3.77) | 0.762 | 1.07 (0.34–3.38) | 0.913 | |
* Model 1, adjusted for age, sex, and BMI; ** Model 2, adjusted for Model 1 + cognitive impairment, TTS within 48h, physiotherapy, fracture type; # Four patients were excluded: 2 with plasma TSH 4.20 mIU/L, high FT4 and normal FT3; ## Hypothyroidism, plasma TSH >4.20 mIU/L, along with low FT3 or FT4 levels; ### Subclinical hypothyroidism, plasma TSH > 4.20 mIU/L but other thyroid hormone (FT3 and FT4) levels are normal; @ Hyperthyroidism, plasma TSH < 0.27mIU/L, along with elevated levels of FT3 or FT4; @@ Subclinical hyperthyroidism, plasma TSH TSH – thyroid-stimulating hormone; HR – hazard ratio; CI – confidence interval; Q1 – the first quartile; Q2 – the second quartile; Q3 – the third quartile; Q4 – the fourth quartile; BMI – body mass index; TTS – time to surgery; TSH – thyroid-stimulating hormone; FT3 – free triiodothyronine; FT4 – free thyroxine. |