Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

05 August 2024 : Clinical Research  

Preoperative Thyroid-Stimulating Hormone Levels and Three-Year Mortality in Elderly Hip Fracture Patients: Insights from a Prospective Cohort Study

Yimin Chen ORCID logo123ABCDEF, Chao Tu123EF, Gang Liu123ABDG, Mingjian Bei456BF, Jing Zhang57CD, Zhelun Tan123BF, Yufeng Ge123BF, Weidong Peng123BF, Feng Gao ORCID logo123BD, Maoyi Tian89AB, Minghui Yang123ABG*, Xinbao Wu123ABC

DOI: 10.12659/MSM.944465

Med Sci Monit 2024; 30:e944465

Table 2 Unadjusted and adjusted association between admission TSH and 3-year mortality.

TSH (mIU/L)Events, n (%)UnadjustedModel 1*Model 2**
HR (95% CI)P-valueHR (95% CI)P-valueHR (95% CI)P-value
ContinuousPer 1153 (20.6)0.97 (0.90–1.04)0.3460.98 (0.92–1.05)0.6300.98 (0.92–1.05)0.639
Dichotomy<1.6485 (22.7)1 (Reference)1 (Reference)1 (Reference)
≥1.6468 (18.5)0.79 (0.58–1.09)0.1570.88 (0.64–1.22)0.4480.86 (0.62–1.20)0.379
QuartileQ1 (<0.98)42 (22.0)1 (Reference)1 (Reference)1 (Reference)
Q2 (0.98–1.64)43 (23.5)1.1 (0.72–1.69)0.6501.14 (0.75–1.76)0.5361.13 (0.73–1.74)0.575
Q3 (1.64–2.86)37 (19.9)0.9 (0.58–1.40)0.6390.96 (0.62–1.50)0.8670.93 (0.6–1.46)0.768
Q4 (≥2.86)31 (17.1)0.77 (0.48–1.22)0.2620.92 (0.58–1.47)0.7270.9 (0.56–1.44)0.664
Thyroid function status# Normal (0.27–4.20)128 (20.6)1 (Reference)1 (Reference)1 (Reference)
Hypo## 11 (33.3)1.67 (0.90–3.09)0.1031.38 (0.74–2.56)0.3111.34 (0.72–2.49)0.359
Subclinical-hypo### 8 (11.8)0.54 (0.27–1.11)0.0950.76 (0.37–1.56)0.4520.77 (0.38–1.60)0.489
Hyper@ 1 (16.7)0.72 (0.10–5.15)0.7431.07 (0.15–7.67)0.9491.15 (0.16–8.30)0.890
Subclinical-hyper@@ 3 (33.3)1.59 (0.51–4.99)0.4281.19 (0.38–3.77)0.7621.07 (0.34–3.38)0.913
* Model 1, adjusted for age, sex, and BMI;
** Model 2, adjusted for Model 1 + cognitive impairment, TTS within 48h, physiotherapy, fracture type;
# Four patients were excluded: 2 with plasma TSH 4.20 mIU/L, high FT4 and normal FT3;
## Hypothyroidism, plasma TSH >4.20 mIU/L, along with low FT3 or FT4 levels;
### Subclinical hypothyroidism, plasma TSH > 4.20 mIU/L but other thyroid hormone (FT3 and FT4) levels are normal;
@ Hyperthyroidism, plasma TSH < 0.27mIU/L, along with elevated levels of FT3 or FT4;
@@ Subclinical hyperthyroidism, plasma TSH
TSH – thyroid-stimulating hormone; HR – hazard ratio; CI – confidence interval; Q1 – the first quartile; Q2 – the second quartile; Q3 – the third quartile; Q4 – the fourth quartile; BMI – body mass index; TTS – time to surgery; TSH – thyroid-stimulating hormone; FT3 – free triiodothyronine; FT4 – free thyroxine.

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750