The Influence of Acid-Base Balance on Anesthetic Muscle Relaxants: A Comprehensive Review on Clinical Applications and Mechanisms

01 July 2024 : Review article

Paweł Radkowski

^123ABCDEFG, Maciej Szewczyk

^4ABCDEFG*, Aleksandra Czajka

^12F, Milena Samiec

^12F, Małgorzata Braczkowska-Skibińska

^1FG

DOI: 10.12659/MSM.944510

Med Sci Monit 2024; 30:e944510

Introduction Acid-Base Balance Disturbances Characteristic of Non-Depolarizing Muscle Relaxants The Use of Non-Depolarizing Muscle Relaxants in Acidosis and Alkalosis Characteristic of Depolarizing Muscle Relaxants The Use of Depolarizing Muscle Relaxants in Acidosis and Alkalosis Monitoring and Management Use of Muscle Relaxants in Metabolic and Neuromuscular Disorders Future Directions Conclusions References

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Table 3 Characteristics that the “ideal” NMBDs should have.

An available and adequate antagonist

Rapid onset of action

Short duration of action

No active metabolites

No accumulations in the body

Organ-dependent drug metabolism and elimination

No cardiovascular side effect

NMBDs – non-depolarizing muscle drugs.

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