08 February 2025 : Clinical Research
Immune Dysregulation in Acute Herpes Zoster: Predictive Factors for Postherpetic Neuralgia
Meidi Wang BCDE 1, Yanrong Yuan BCDE 1, Jun Wang ABCF 1, Yongxing Yan ACDFG 1*, Huiqin Yu ABEF 2DOI: 10.12659/MSM.944688
Med Sci Monit 2025; 31:e944688
Table 3 Comparison of cellular and humoral immune functions in HZ patients of different age groups.
| <50 years group (n=73) | 50–79 years group (n=55) | ≥80 years group (n=60) | F | P | |
|---|---|---|---|---|---|
| Age (years) | 36.3±7.7 | 64.5±8.0 | 84.7±3.7 | 852.7 | 0.0001 |
| Sex (n, %) | |||||
| Male | 45 (62%) | 24 (44%) | 33 (55%) | 4.1179 | 0.1276 |
| Female | 28 (38%) | 31 (56%) | 27 (45%) | ||
| Disease duration (days) | 5.0±2.5 | 7.2±3.8 | 5.2±3.0 | 9.564 | 0.0001 |
| Combined diseases (n, %) | |||||
| Hypertension | 6 (8%) | 10 (18%) | 36 (60%) | 47.6202 | 0.0001 |
| Coronary heart disease | 1 (1%) | 2 (4%) | 6 (10%) | 5.6071 | 0.0606 |
| Stroke | 0 | 2 (4%) | 12 (20%) | 20.7504 | 0.0001 |
| Diabetes | 0 | 4 (7%) | 0 | 9.8830 | 0.0071 |
| C3 (g/L) | 1.2±0.2 | 1.2±0.2 | 1.2±0.2 | 0.7368 | 0.4801 |
| C4 (g/L) | 0.4±0.1 | 0.4±0.2 | 0.4±0.1 | 1.453 | 0.2367 |
| IgA (g/L) | 2.4±1.2 | 2.3±0.9 | 2.2±0.8 | 0.4301 | 0.6511 |
| IgG (g/L) | 11.8±3.1 | 12.1±2.8 | 11.9±2.7 | 0.1637 | 0.8492 |
| IgM (g/L) | 1.1±0.9 | 1.1±0.5 | 0.9±0.5 | 2.483 | 0.0864 |
| CD3+ (×10/L) | 1157.5±496.5 | 1007.8±422.2 | 786.0±387.1,** | 11.39 | 0.0001 |
| CD19+ (×10/L) | 249.2±153.0 | 204.8±116.5 | 113.4±77.5,** | 20.08 | 0.0001 |
| CD8+ (×10/L) | 470.4±292.9 | 377.9±181.5 | 304.6±174.6** | 8.523 | 0.0003 |
| CD4+ (×10/L) | 598.0±288.6 | 579.3±282.8 | 440.6±261.7,** | 5.796 | 0.0036 |
| CD56+ (×10/L) | 263.6±158.0 | 236.7±114.4 | 281.4±177.7 | 1.215 | 0.2991 |
| CD4+/CD8+ | 1.7±1.2 | 1.7±0.9 | 1.8±1.1 | 0.2704 | 0.7634 |
| Compared with the * ** # ## | |||||