Impact of Tigecycline on Coagulation in Severe Infections and Effect of Vitamin K1 Intervention: A Retrospective Single-Center Analysis

03 November 2024 : Database Analysis

Haiyan Sun^12ABCDEFG, Xianqing Meng^3BDE, Xupeng Shao^1BCF, Liyun Duan^1DF, Kailiang Fan^1ACFG*

DOI: 10.12659/MSM.944778

Med Sci Monit 2024; 30:e944778

Introduction Material and Methods Results Discussion Conclusions References

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Table 4 Effect of vitamin K1 intervention on coagulation indices.

Group	Treatment	APTT	PT	Fib
High-dose group (56)	Pre-treatment	68.43±4.68	22.23±2.69	1.41±1.90
	Post-treatment	53.23±4.52	19.66±2.02	1.90±0.23
		<0.01	<0.05	<0.05
Normal-dose group (16)	Pre-treatment	62.18±3.04	20.49±1.60	1.75±0.22
	Post-treatment	50.89±3.81	17.57±1.16	2.36±0.26
		<0.01	<0.05	<0.01
Compared with before treatment, APTT and PT were significantly shortened (

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