09 July 2024 : Clinical Research
Prognostic Significance of Thrombocytopenia and Mean Platelet Volume in COPD Patients with Acute Exacerbations in ICU Settings
Melek Doganci
1ABCDEFG*, Guler Eraslan Doganay 1ABCDEFG
DOI: 10.12659/MSM.944946
Med Sci Monit 2024; 30:e944946
Table 2 Investigation of 1-month mortality in COPD patients.
| Mortality (−) (n=318) | Mortality (+) (n=154) | P | |||
|---|---|---|---|---|---|
| χ̄±SD | Med (IQR) | χ̄±SD | Med (IQR) | ||
| BMI | 25.91±6.9 | 25.1 (7.8) | 25.3±6.12 | 24.2 (6.1) | .24* |
| Age (year) | 69.29±11.34 | 68.5 (15) | 74.25±10.89 | 74 (15) | * |
| Gender, n (%) | .87# | ||||
| Male | 200 (62.9%) | 98 (63.6%) | |||
| Female | 118 (37.1%) | 56 (36.4%) | |||
| Inotropic agent support, n (%) | 26 (8.2%) | 76 (49.4%) | |||
| APACHE-II | 19.28±4.95 | 19 (6) | 26.47±8.06 | 26 (11) | * |
| Length of hospital stay (day) | 19.88±16.69 | 15 (13) | 16.38±13.49 | 12 (17) | * |
| Length of stay ICU (day) | 4.69±5.52 | 3 (4) | 6.75±7.73 | 3 (6) | .05* |
| Neutrophil (K/μl) | 8.91±4.59 | 7.8 (5.9) | 13.03±12.23 | 10.6 (8.7) | * |
| MPV (fl) | 8.66±1.52 | 8.5 (2) | 9.01±1.72 | 8.6 (1.5) | .09* |
| ALT (IU/L) | 44.28±191.75 | 18 (17) | 119.47±507.21 | 21 (26) | * |
| AST (IU/L) | 54.98±325.32 | 22 (19) | 120.87±435.97 | 26 (26) | * |
| Albumin (g/dL) | 3.36±0.5 | 3.4 (0.7) | 2.91±0.53 | 3 (0.8) | * |
| CCIS | 5.36±1.67 | 5 (2) | 6.53±2.25 | 6 (3) | * |
| MV Duration (day) | 1.36±5.26 | 0 (0) | 5.57±8.35 | 2 (4) | * |
| Leukocyte (K/μl) | 10.9±4.56 | 10.25 (6) | 15.33±13.28 | 12.5 (8.8) | * |
| Lymphocyte (K/μl) | 1.2±1.65 | 0.9 (0.78) | 1.27±1.21 | 0.8 (1.38) | .81* |
| Lymphocyte% | 11.08±8.65 | 9.4 (9.3) | 10.23±9.44 | 6.3 (10.46) | * |
| Neutrophil % | 81.77±13.16 | 83.9 (13.8) | 83.31±12.44 | 87.1 (14.8) | .06* |
| Plt (cell ×10/L) | 244.54±95.08 | 227.5 (124) | 215.01±103.69 | 194 (125) | * |
| CRP (mg/L) | 5.44±6.29 | 2.9 (6.75) | 10.86±9.93 | 7.6 (15.4) | * |
| Procalcitonin (ng/mL) | 0.75±2.51 | 0.14 (0.55) | 5.21±16.03 | 0.31 (2.07) | * |
| SOFA score | 5.52±0.97 | 5 (1) | 8.1±2.57 | 8 (3) | * |
| * Mann-Whitney U test; # Pearson’s chi-square test or Fisher exact test.Statistically significant p-values are in bold. BMI – body mass index; APACHE-II – Acute Physiology and Chronic Health Evaluation; ICU – Intensive Care Unit; MPV – mean platelet volume; ALT – alanine transaminase; AST – aspartate transaminase; CCIS – Charlson Comorbidity Index Score; MV – mechanical ventilation; Plt – platelet; CRP – C-reactive protein; SOFA – Sequential Organ Failure Assessment | |||||