Oxidative and Antioxidative Biomarker Profiles in Neonatal Hypoxic-Ischemic Encephalopathy: Insights for Pathophysiology and Treatment Strategies

17 August 2024 : Clinical Research

Nur Aycan^1ABCDEFG*, Derya Çay Demir^2ABDF, Eyyüp Yürektürk^3BFG, Murat Başaranoğlu^3DFG, Serap Karaman^3BFG, Oğuz Tuncer^3BDG

DOI: 10.12659/MSM.945045

Med Sci Monit 2024; 30:e945045

Introduction Material and Methods Results Discussion Conclusions References

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Table 2 First blood gas and biochemical measurements of newborns with hypoxia and healthy newborns.

Parameter	HIE (n=59)	Control (n=32)	P value
Initial pH^*	7.08±0.008	7.40±0.07	0.0001
Initial pCO^*	53.42±1.78	42.08±0.49	0.0001
Initial pO^*	63.15±1.78	79.17±1.39	0.0001
Initial HCO (mmol/L)^*	15.1±0.39	22.52±0.39	0.0001
Initial base excess (mEq/La)^*	−17.12±0.25	1.82±0.53	0.0001
Lactate (mmol/L)^*	9.27±0.36	1.78±0.09	0.0001
Blood urea nitrogen (mg/dL)^**	12.05±0.36	7.5±0.17	0.0001
Creatinine (mg/dL)^**	0.98±0.03	0.6±0.04	0.0001
Creatine kinase (U/L)^**	2085.15±141.13	571.17±39	0.0001
AST (U/L)^**	240.4±54.4	96.65±2.6	0.085
ALT (U/L)^**	93.01±18.2	29.04±2.2	0.024
Lactate dehydrogenase (U/L)^**	1395±57.33	358.52±18.3	0.0001
Uric acid (mg/dL)^**	8.22±0.23	4.84±0.19	0.0001
^* Blood gas; ^** Plasma. pH – potential of hydrogen; pCO – partial carbon dioxide; pO – partial oxygen; HCO – bicarbonate; AST – aspartate aminotransferase; ALT – alanine aminotransferase.

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