Impact of Traditional Chinese Medicine Antioxidants on Oxidative Stress and Drug-Induced Liver Injury: A Review

Jing Zhao; He Liang; Yanrong Li; Zimeng Xu; Xueqin Li; Lulu Zhao; Mengqian Zhang; Xuehui Duan

doi:10.12659/MSM.945147

11 December 2024 : Review article

Impact of Traditional Chinese Medicine Antioxidants on Oxidative Stress and Drug-Induced Liver Injury: A Review

Jing Zhao^{AEF 1*}, He Liang^{BF 1}, Yanrong Li^{FG 2}, Zimeng Xu^{B 3}, Xueqin Li^{B 3}, Lulu Zhao^{B 3}, Mengqian Zhang^{B 3}, Xuehui Duan^{B 3}

DOI: 10.12659/MSM.945147

Med Sci Monit 2024; 30:e945147

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Introduction ROS, Free Radicals, and Human Health Antioxidant Intake and Human Health Pathogenesis and Treatment of DILI Oxidative Stress and DILI Antioxidants Are Widely Found in TCM Repair Mechanism of DILI by Antioxidants in TCM Future Directions Conclusions References

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Table 2 Extracts from TCMs used to treat DILI in rats.

Latin name	Antioxidant	Mechanism	Ref
	Methanol extract	Increased SOD, CAT, and activity	[]⁹⁷
	Polyphenols	Increased SOD, CAT, and GST activity	[]⁹⁸
	Polyphenols	Increased SOD and GPX activity	[]⁹⁹
	Lignans	Increased SOD and GPX activity	[]¹⁰⁰
	Methanol extract	Regulation of lipid metabolism	[]²⁸
	Ginsenoside	Increased SOD, CAT, and GPX activity	[]¹⁰¹
	Betaine	Increased SOD, CAT, and GPX activity	[]¹⁰²
	Water extract	Increased SOD, CAT, and GPX activity	[]¹⁰³
	Glycoside	Increased SOD, CAT, and GPX activity	[]⁸⁹
TCM – Traditional Chinese Medicine; DILI – drug-induced liver injury; SOD – superoxide dismutase; CAT – catalase; GPX – glutathione peroxidase; GST – glutathione-S-transferase.

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Impact of Traditional Chinese Medicine Antioxidants on Oxidative Stress and Drug-Induced Liver Injury: A Review

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