28 November 2024 : Review article
Enhanced Diagnostic Imaging: Arrival-Time Parametric Imaging in Contrast-Enhanced Ultrasound for Multi-Organ Assessment
Nan Jiang1ABCDEF, Jun-Ying Cao2ABCDEF, Zhuang Jin1CDG, Tian-Qi Yu3DE, Shu-Ting Chen4CDE, Yun Zhang1ABDE*DOI: 10.12659/MSM.945281
Med Sci Monit 2024; 30:e945281
Table 1 Summary of the preclinical studies and clinical trials by At-PI, in which the results have been reported.
| Organs | Time | Device | Dose of microbubbles | Mechanical index | Ultrasonic probe (pulse repetition frequency) | Frame rate (per second) | Country | References |
|---|---|---|---|---|---|---|---|---|
| Liver | 2007 | Aplio SSA-790A | SonoVue 0.1–0.2 mL/min | 0.06, 0.08 | 3.75 MHz, 7.0 MHz | 15 | Japan | Sugimoto K, Moriyasu F, Kamiyama N, et al []6 |
| Liver | 2022 | LOGIQ E9 | SonoVue 2.5 mL | – | C1–6 | – | Romania | Lupuşoru R, Sporea I, Ra-iu I, et al []7 |
| Liver | 2020 | LOGIQ E9 | SonoVue 2 mL | 0.11–0.13 | C1–5 | – | China | Wu XF, Bai XM, Yang W, et al []8 |
| Liver | 2013 | Aplio SSA-790A | Sonazoid 0.5 mL | 0.22–0.29 | PSK-375BT (3.75 MHz) | – | Japan | Wakui N, Takayama R, Kamiyama N, et al []10 |
| Liver | 2015 | Aplio SSA-770A/500 | SonoVue 2.4 mL | 0.06–0.10 | 375BT (3.0 or 3.5 MHz) | – | China | Li W, Wang W, Liu GJ, et al []11 |
| Liver | 2008 | Aplio SSA-770A | SonoVue 1.5 mL | 0.07–0.08 | PSK-375BT (3.75 MHz) | 15 | Japan | Sugimoto K, Moriyasu F, Kamiyama N, et al []12 |
| Liver | 2010 | Aplio SSA-790A | Sonazoid 0.5 mL | 0.2 | PSK-375BT (3.75 MHz) | – | Japan | Watanabe M, Shiozawa K, Takahashi M, et al []14 |
| Liver | 2022 | LOGIQ E9 | SonoVue 1.5 mL | 0.12 | C5-1(2.0~4.0 MHz) | – | China | Liu YH, Fan ZH, Yin SS, et al []15 |
| Liver | 2012 | Aplio SSA-790A | Sonazoid 0.5 mL | 0.2 | PSK-375BT (3.75 MHz) | – | Japan | Shiozawa K, Watanabe M, Kikuchi Y, et al []16 |
| Liver | 2017 | SSA-790A | Sonazoid 0.5 mL | 0.2 | PSK-375BT (3.75 MHz) | – | Japan | Shiozawa K, Watanabe M, Ikehara T, et al []17 |
| Liver | 2011 | Aplio SSA-790A | Sonazoid 0.015 mL/kg | 0.22–0.29 | PSK-375BT (3.75 MHz) | 15–18 | Japan | Wakui N, Takayama R, Mimura T, et al []21 |
| Liver | 2012 | Aplio SSA-790A | Sonazoid 0.015 mL/kg | 0.22–0.29 | PSK-375BT (3.75 MHz) | 15–18 | Japan | Wakui N, Takayama R, Kanekawa T et al []23 |
| Liver | 2018 | SSA-790A | Sonazoid 0.015 mL/kg | 0.22–0.29 | PVT-375BT | 15–18 | Japan | Wakui N, Nagai H, Matsukiyo Y, et al []24 |
| Liver | 2018 | SSA-790A | Sonazoid 0.015 mL/kg | 0.22–0.29 | PVT-375BT | 15–18 | Japan | Wakui N, Nagai H, Ogino Y, et al []25 |
| Liver | 2022 | SSA-790A | Sonazoid 0.015 mL/kg | 0.22–0.29 | PSK-375BT (3.75 MHz) | 15–18 | Japan | Yoshimine N, Wakui, N, Nagai H, et al []26 |
| Liver | 2013 | Aplio SSA-790A | Sonaziod 0.015 mL/kg | 0.21 | PSK-375BT (3.75 MHz) | – | Japan | Wakui N, Takayama R, Matsukiyo Y, et al []27 |
| Liver | 2013 | Aplio SSA-790A | Sonazid 0.5 mL | 0.2 | PSK-375BT (3.75 MHz) | – | Japan | Shiozawa K, Watanabe M, Takayama R, et al []28 |
| Liver | 2013 | Aplio SSA-790A | Sonazoid 0.015 mL/kg | 0.21 | PSK-375BT (3.75 MHz) | – | Japan | Wakui N, Fujita M, Oba, N et al []29 |
| Adrenal | 2015 | Aplio XG | Sonovue 2.4 mL | 0.06–0.09 | Convex probe (1–6 MHz) | – | Poland | Slapa RZ, Kasperlik-Zaluska AA, Migda B, et al []30 |
| Breast | 2016 | LOGIQ S8 | Sonazoid 0.01 mL/kg | 0.18–0.22 | 11L | – | Japan | Noro A, Nakamura T, Hirai T, et al []31 |
| Breast | 2020 | LOGIQE9 | SonoVue 4.5 mL | 0.9–1.2 | 9L (5–9 MHz) | – | China | Hu W, Dong Y, Zhang X, et al []32 |
| Lymph nodes | 2018 | LOGIQ E9 | SonoVue 1 mL | 0.10–0.13 | 9L (5–9 MHz) | – | China | Yin SS, Cui QL, Fan ZH, et al []33 |
| Prostate | 2020 | LOGIQ E9 | SonoVue 2.4 mL | – | convex probe (1–6 MHz) | – | Germany | Jung EM, Wertheimer T, Putz FJ, et al []34 |
| Prostate | 2021 | LOGIQ E9 | SonoVue 2.0–2.4 mL | <0.2 | C1–6 | – | Germany | Jung EM, Engel M, Wiggermann P, et al []35 |
| Gastrointestinal tract | 2021 | LOGIQ E9/S8 | SonoVue 1.5–2.4 mL | <0.2 | convex sector transducer 1–6 MHz/high-resolution linear multifrequency transducer 6–9 MHz | – | Germany | Pausch AM, Kammerer S, Weber F, et al []36 |
| Gastrointestinal tract | 2022 | LOGIQ E9 | SonoVue 1.5–2.4 mL | <0.2 | convex sector transducer 1–6 MHz/high-resolution linear multifrequency transducer 6–9 MHz | – | Germany | Tews HC, Kandulski A, Schmid S, et al []37 |