18 August 2024 : Review article
Optimizing Mesenchymal Stem Cells for Regenerative Medicine: Influence of Diabetes, Obesity, Autoimmune, and Inflammatory Conditions on Therapeutic Efficacy: A Review
Dominika Przywara1ABCDEF, Alicja Petniak
1BCDEF, Paulina Gil-Kulik 1ABCDEFG*
DOI: 10.12659/MSM.945331
Med Sci Monit 2024; 30:e945331
Introduction
Characterization of Human Mesenchymal Stem Cells (MSCs)
Methods of Harvesting MSCs
Banking of MSCs
Paracrine Signaling via Cytokines, Growth Factors, and Small Molecules
MSCs and Diabetes
MSCs and Obesity
MSCs and Autoimmune Diseases
MSCs and Inflammatory Diseases
Other Factors and Medical Conditions
Paracrine Properties of MSCs Depending on Their Source
Future Directions – Regenerative Medicine
Conclusions
References
Table 2 Comparison of properties for angiogenesis, proliferation, anti-inflammatory properties, cell aging, genotoxic stress, and exosome size and number in O-MSCs/MS-MSCs and H-MSC.
| Parameter | O-MSCs/MS-MSCs | H-MSCs |
|---|---|---|
| Angiogenesis | Exosomes contain reduced amounts of VEGF, MMP2 and miR126 []41 | , improve vascular remodeling []↑ |
| Proliferation | ↓ [,]18 | [,]↑ |
| Anti-inflammatory properties | α, , i β []↑ | ↓ α, , i []40 |
| Cell aging | []↑ | ↓ []39 |
| Genotoxic stress | In the secretome the presence of proteins involved in the repair of DNA damage []39 | 0 |
| Exosome size | ↓ []42 | []↑ |
| Number of exosomes | []↑ | ↓ []42 |
| ↑ – increase; ↓ – decrease; 0 – absent. | ||