25 September 2024 : Clinical Research
Enhanced Differentiation of Amiodarone-Induced Thyrotoxicosis Types Using Semi-Quantitative 99mTc-MIBI Uptake Analysis: A Pilot Study
Leo Fischer1BDEF, Neva Girotto1DE*, Maja Ilić Tomaš1BDE, Martina Mavrinac
2CD, Andrica Lekić3CD, Dragana Antončić 4BD, Tatjana Bogović Crnčić1ADE
DOI: 10.12659/MSM.945444
Med Sci Monit 2024; 30:e945444
Table 1 Imaging data of patients with amiodarone-induced thyrotoxicosis (AIT) categorized in 3 groups (AIT-1, AIT-2 and AIT-3), according to the visual analysis of the 99mTc-Methoxy-2-Isobutylisonitrile (MIBI) uptake.
| Patients | AIT groups according to visual MIBI uptake | Thyroid ultrasonography | Scintigraphy with 99mTc pertechnetate | |||
|---|---|---|---|---|---|---|
| Volume | AITD | CDFS | Nodules | |||
| 1 | 1 | 2 | − | 0 | + | − |
| 2 | 1 | 2 | + | 0 | + | − |
| 3 | 1 | 1 | − | 2 | − | + |
| 4 | 1 | 2 | + | 2 | − | + |
| 5 | 1 | 2 | − | 0 | + | − |
| 6 | 1 | 2 | − | 0 | + | + |
| 7 | 1 | 3 | + | 0 | + | NA |
| 8 | 1 | 2 | + | 0 | + | − |
| 9 | 1 | 3 | + | 0 | − | − |
| 10 | 1 | 2 | − | 0 | − | − |
| 11 | 1 | 2 | − | NA | + | − |
| 12 | 1 | 2 | − | 0 | + | − |
| 13 | 1 | 1 | + | 0 | − | − |
| 14 | 2 | 1 | − | NA | + | − |
| 15 | 2 | 1 | − | 1 | − | − |
| 16 | 2 | 2 | − | 0 | − | − |
| 17 | 2 | 1 | + | 0 | − | − |
| 18 | 2 | 1 | − | 0 | + | − |
| 19 | 2 | 3 | − | 2 | + | − |
| 20 | 2 | 1 | + | 0 | − | − |
| 21 | 2 | 2 | + | 0 | − | − |
| 22 | 2 | 1 | + | 0 | − | − |
| 23 | 2 | 1 | − | 2 | − | + |
| 24 | 2 | 1 | − | 0 | + | − |
| 25 | 2 | 2 | + | 0 | − | NA |
| 26 | 3 | 2 | − | NA | + | − |
| 27 | 3 | 3 | − | 2 | + | − |
| 28 | 3 | 2 | + | 2 | − | − |
| 29 | 3 | 2 | − | 0 | − | − |
| 30 | 3 | 1 | + | 2 | − | − |
| 31 | 3 | 1 | − | 0 | + | − |
| 32 | 3 | 2 | + | 0 | + | − |
| 33 | 3 | 2 | − | 0 | + | − |
| 34 | 3 | 1 | + | 0 | − | NA |
| 35 | 3 | 1 | + | 0 | + | − |
| 36 | 3 | 1 | − | 0 | − | NA |
| AIT – amiodarone-induced thyrotoxicosis; MIBI – Tc-Methoxy-2-Isobutylisonitrile; AITD – autoimmune thyroid disease (present +, absent –), thyroid ultrasonography (volume within – 1, above – 2, below normal range – 3); CDFS – color Doppler flow sonography (normal – 0, mildly increased – 1, markedly increased vascularization – 2), thyroid nodules (present +, absent -), scintigraphy with Tc-pertechnetate (uptake higher than background +, only background activity –); NA – not available. | ||||||