Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

05 November 2024 : Review article  

Epigenetic and Immune Mechanisms Linking Breastfeeding to Lower Breast Cancer Rates

Laura Maria Surdacka ORCID logo1ABCDEF, Adam Jakubas ORCID logo1CDEF, Jakub Jagiełło ORCID logo1CDEF, Karolina Daniłowska ORCID logo1CDEF, Natalia Picheta ORCID logo1CDEF, Paulina Gil-Kulik ORCID logo2ADEG*

DOI: 10.12659/MSM.945451

Med Sci Monit 2024; 30:e945451

Table 2 The impact of pregnancy and breastfeeding on breast stem cells.

ParameterPregnancyBreastfeedingReferences
Quantity[,]47
The ability to differentiate[,]36
Proliferation[,]78
Activity of pluripotency genes and proteins (OCT4, SOX2, hNANOG)[,]90
potential for cancer↑*[,]70
Anti-inflammatory effect[,]85
Influence on signaling pathways↓Wnt signalingNo effect demonstrated[]94
OCT4 – including POU class 5 homeobox 1; SOX2 – sex-determining region Y-box 2; hNANOG – nanog homeobox; Wnt – wingless-related integration site; ↑ – increase; ↓ – decrease.

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750