05 November 2024 : Review article
Epigenetic and Immune Mechanisms Linking Breastfeeding to Lower Breast Cancer Rates
Laura Maria SurdackaDOI: 10.12659/MSM.945451
Med Sci Monit 2024; 30:e945451
Table 2 The impact of pregnancy and breastfeeding on breast stem cells.
| Parameter | Pregnancy | Breastfeeding | References |
|---|---|---|---|
| Quantity | ↑ | ↓ | [,]47 |
| The ability to differentiate | ↑ | ↑ | [,]36 |
| Proliferation | ↑ | ↑ | [,]78 |
| Activity of pluripotency genes and proteins (OCT4, SOX2, hNANOG) | ↑ | ↑ | [,]90 |
| potential for cancer | ↑* | ↓ | [,]70 |
| Anti-inflammatory effect | ↑ | ↑ | [,]85 |
| Influence on signaling pathways | ↓Wnt signaling | No effect demonstrated | []94 |
| OCT4 – including POU class 5 homeobox 1; SOX2 – sex-determining region Y-box 2; hNANOG – nanog homeobox; Wnt – wingless-related integration site; ↑ – increase; ↓ – decrease. | |||






