24 October 2024 : Review article
Strategies for Managing Pediatric Fracture Pain: Assessment, Pharmacological, and Non-Pharmacological Interventions
Mengsha Hu1E, Yongwei Shang2AF*DOI: 10.12659/MSM.945497
Med Sci Monit 2024; 30:e945497
Table 4 Dose suggestions of pediatric analgesic medications, including nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids.
| Medicine | Category | Formulations | Pediatric dosage |
|---|---|---|---|
| Ibuprofen | NSAID | Rectal, oral, intravenous | >3 months, 5–10 mg/kg, every 6–8 h, max of 40 mg/kg/day |
| Naproxen | NSAID | Rectal, oral, intravenous | >3 months, 5–10 mg/kg, every 8–12 h |
| Diclofenac | NSAID | Rectal, oral, intravenous | Rectal, oral, every 8 h >1 year old, 1 mg/kg,Intravenous, every 8 h >1 year old, 0.3 mg/kg |
| Acetaminophen | NSAID | Rectal, oral, intravenous | Rectal, every 6 h, max of 100 mg/kg/day ><10 kg, 15 mg/kg; >10 kg, 20–40 mg/kgOral, every 4–6 h, max of 100 mg/kg/day >10–15 mg/kg,Intravenous every 6 h ><10 kg, 7.5 mg/kg, max of 30 mg/kg/day >10–50 kg, 15 mg/kg, max of 60 mg/kg/day >>50 kg, 1 g, max of 4 g/day |
| Celecoxib | NSAID | Oral | >6 months, 1–2 mg/kg, every 12 h |
| Morphine | Opioid | Oral | 0–30 days, 0.025–0.05 mg/kg, every 4–6 h1–6 months, 0.1 mg/kg, every 4–6 h>6 months, 0.15–0.3 mg/kg, every 2–4 h |
| Hydromorphone | Opioid | Oral | 0.03–0.08 mg/kg, every 3–4 h |
| Meperidine | Opioid | Oral | >1 years old, 1.1–1.8 mg/kg, every 3–4 h |
| Fentanyl | Opioid | Intravenous, intranasal | Intravenous every 2–4 h 0–12 months, 1–2 μg/kg; >12 months, 0.5–1 μg/kg,Intranasal (second dose after 30 min) >10 kg, 1.5 μg/kg, max of 75 μg/dose |
| Oxycodone | Opioid | Oral | ≤6 months, 0.025–0.05 mg/kg, every 3–4 h>6 months, every 3–4 h<50 kg, 0.1–0.2 mg/kg; >50 kg, 5–10 mg |
| Methadone | Opioid | Intravenous | 0.05–0.1 mg/kg, every 12 h, max of 30 mg/day |