01 March 2025 : Clinical Research
Time-Sensitive Antibiotic Adjustments in Gram-Negative Bacteremia: A Survival Perspective
Yunwei Zheng ABCDEF 1, Chuwen Zhao ABCDEF 1,2, Bo Liao EF 3, Fuxing Li ABC 1, Yaping Hang ACD 1, Junqi Zhu BCE 1,2, Youling Fang CDF 1,2, Yanhua Liu BDEF 1, Longhua Hu ADEG 1*DOI: 10.12659/MSM.945569
Med Sci Monit 2025; 31:e945569
Table 4 Univariate and multivariate Cox regression analysis of 30-day mortality after propensity score-matched (PSM) analysis.
| Characteristic | Univariable | Multivariable | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Pitt score | 1.31 | 1.19–1.44 | <0.001 | 1.42 | 1.25–1.62 | <0.001 |
| aCCI score | 1.22 | 1.04–1.42 | 0.014 | 1.45 | 1.20–1.76 | <0.001 |
| Lung infections | 2.63 | 1.23–5.62 | 0.012 | 2.00 | 0.78–5.11 | 0.149 |
| Immune compromise | 0.43 | 0.10–1.82 | 0.254 | 0.18 | 0.04–0.83 | 0.028 |
| Diabetes | 0.75 | 0.26–2.15 | 0.587 | 0.29 | 0.09–0.93 | 0.037 |
| ITD | 1.06 | 1.01–1.10 | 0.010 | 1.07 | 1.01–1.12 | 0.018 |
| ATD | 0.86 | 0.78–0.95 | 0.002 | 0.84 | 0.75–0.93 | <0.001 |
| aCCI – age-adjusted Charlson Comorbidity Index; ITD – inappropriate treatment days; ATD – appropriate treatment days; HR – Hazard Ratio; CI – confidence interval. | ||||||