Prospective Analysis of Central Nervous System Infection Risks in Varicella-Zoster Virus Reactivation Cases: A Single-Center Prospective Study of 1030 Cases

29 December 2024 : Clinical Research

Jun Wang^{ABEG 1*}, Yanrong Yuan^{BEF 1}, Huili Liu^{BCF 1}, Yan Zhang^{EF 1}, Yongxing Yan^{ACDG 1}

DOI: 10.12659/MSM.945835

Med Sci Monit 2024; 30:e945835

Introduction Material and Methods Results Discussion Conclusions References

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Table 2 Comparison of serum marker levels between the 2 groups (x±SD).

	HZ group (n=990)	VZV-associated CNS infection group (n=40)	T	P
Cellular immune function
CD3+ (×10/L)	889.7±437.8	845.3±385.4	0.547	0.585
CD19+ (×10/L)	174.7±126.8	186.2±131.3	0.489	0.625
CD8+ (×10/L)	357.3±414.7	326.9±165.8	0.400	0.690
CD4+ (×10/L)	504.2±355.0	477.1±248.4	0.415	0.678
CD56+ (×10/L)	263.7±187.3	203.5±92.3	1.752	0.080
CD4+/CD8+	1.8±1.5	2.0±1.2	0.666	0.506
Humoral immune function
C3 (g/L)	1.2±0.3	1.3±0.3	1.214	0.225
C4 (g/L)	0.4±0.5	0.4±0.1	0.140	0.889
IgA (g/L)	2.4±1.6	2.7±2.7	0.949	0.343
IgG (g/L)	12.0±4.1	11.7±2.6	0.505	0.614
IgM (g/L)	1.1±0.7	1.0±0.5	0.426	0.670
WBC (×10/L)	6.1±3.1	6.1±2.5	0.138	0.890
RBC (×10/L)	4.3±0.6	4.3±0.5	0.325	0.745
Hemoglobin (g/L)	133.0±17.3	134.2±14.8	0.454	0.650
Blood progenitor cells (×10/L)	207.6±152.5	192.8±51.4	0.613	0.540
Absolute value of lymphocytes (×10/L)	1.43±0.66	1.37±0.70	0.562	0.574
Absolute value of neutrophils (×10/L)	4.1±2.7	4.2±2.2	0.278	0.781
Neutrophil to lymphocyte count ratio	3.4±2.6	3.8±2.9	1.059	0.290
Platelet to lymphocyte counts ratio	173.1±175.7	175.2±111.8	0.047	0.962
C-reactive protein (mg/L)	2.7 (0.8,6.87)	5.6 (3.7,18.5)	7.922	0.001

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