16 January 2025 : Review article
COL3A1 Gene Polymorphism and Its Impact on Female Pelvic Organ Prolapse
Eighty Mardiyan Kurniawati ACG 1*, Nur Anisah Rahmawati BDE 2, Anis Widyasari EF 3DOI: 10.12659/MSM.946367
Med Sci Monit 2025; 31:e946367
Introduction
Female POP: Epidemiology and Risk Factors
Treatment Challenges in Pelvic Organ Prolapse
Role of Collagen in the Pelvic Floor
Collagen 3 Alpha 1 (COL3A1) Gene rs1800255 Polymorphism and Female Pelvic Organs Prolapse
Treatment of Collagen in Pelvic Floor Disorders
Limitations of Current Studies
Future Research Directions
Conclusions
References
Table 1 Recent research on collagen 3 alpha 1 (COL3A1) rs1800255 gene polymorphism and female pelvic organ prolapse.
| Author, year | Type of study | Example | Number of samples | Age | Collagen polymorphism examination method | Finding |
|---|---|---|---|---|---|---|
| Teixeira et al, 2020 []33 | Prospective cohort studies | Women with a clinical diagnosis of stage III and IV prolapse (POP group) and stage 0 or I prolapse (control group) | 112 cases/180 controls | POP 68.4±0.92, Control 57.8±0.70 | Polymerase chain reaction | The rs1800255 polymorphism of the gene is not a risk factor for POP |
| Lince et al, 2014 []38 | Case-control studies | Women with and without POP symptoms | 272 cases/82 controls | Woman with POP 55±13, Control 57±12 | HRM analysis and polymerase chain reaction | The rs1800255 polymorphism of the gene is not a risk factor for POP |
| Batista et al, 2020 []39 | Case-control studies | Postmenopausal women are divided into POP (stages III and IV) and control groups (stages 0 and I) | 348 cases/286 controls | POP 69 (42–92), Control 59 (45–89) | Polymerase chain reaction | The rs1800255 polymorphism of the gene is not a risk factor for POP |
| Ashikari et al, 2021 []40 | Case-control studies | Women with and without POP | 52 cases/28 controls | POP 69.9±7.2, Control 62.8±11.0 | Polymerase chain reaction | The rs1800255 polymorphism of the gene is not a risk factor for POP |
| Martin et al, 2011 []41 | Case-control studies | Patients with stage III and IV genital prolapse (POP-Q) and those with stage 0 and I prolapse | 107 cases/209 controls | POP 66 (43–84) Control 60 (50–84) | Polymerase chain reaction | Polymorphism exon 31 type III collagen is not associated with a higher risk of pelvic genital prolapse |
| Ustyuzhina et al, 2020 []42 | Case-control studies | Women with signs of POP and women with the absence of objectively proven prolapse | 53 cases/215 controls | NA | Real-time polymerase chain reaction | There is a high association of the polymorphism rs1800255 gene with POP |
| Abulaizi et al, 2020 []43 | Prospective studies | Patients with POP and those with non-pelvic floor dysfunction | 88 cases/108 controls | Range 33–53 POP 11 (25) Control 19 (34.5) Range ≥53 POP 33 (75) Control 36 (65.5) | Polymerase chain reaction | The rs1800255 polymorphism of the gene is not a risk factor for POP |