22 December 2024 : Review article
MicroRNAs as Biomarkers for Metabolic Disorders in Polycystic Ovary Syndrome (PCOS): A Review
Izabela Dymanowska1ABCDEF, Karolina Frankowska
2ABCDEF*, Agata Małgorzata Krawczyk2ABCDEF, Julia Kociuba2BCDE, Paulina Gil-Kulik 3ABCDEF, Beata Banaszewska 4ABCDEF, Grzegorz Polak 1ABCDEFG
DOI: 10.12659/MSM.946480
Med Sci Monit 2024; 30:e946480
Introduction
miRNAs in Insulin Resistance (IR)
miRNAs in Obesity
Lipid Metabolism Disorders Characteristic of Polycystic Ovary Syndrome (PCOS)
microRNAs in Triglycerides (TG) Metabolism Disorders
microRNAs in Total Cholesterol (TC) Metabolism Disorders
microRNAs in Low-Density Lipoprotein Cholesterol (LDL-C) Disorders
microRNAs in High-Density Lipoprotein Cholesterol (HDL-C) Disorders
microRNAs in Hypertension
microRNAs in type 2 Diabetes Mellitus
microRNAs in Non-Alcoholic Fatty Liver Disease (NAFLD)
Future Directions
Conclusions
References
Table 1 Associations between dysregulated microRNAs (miRNAs) and insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS).
| Authors | Year | Collected material | Upregulated miRNA | Downregulated miRNA |
|---|---|---|---|---|
| Chen et al []40 | 2013 | Adipose tissue | miR-223; miR-133 | – |
| Murri et al []41 | 2018 | Serum | miR-197-3p; miR-378a-5p; miR-223-5p; miR-122-5p; miR-203a; miR-16-1-3p; miR-193a-5p; miR-378a-3p; miR-24-3p; miR-361-5p; miR-365a-3p; miR-192-5p; miR-1468; miR-425-3p | miR-151a-5p/3p; miR-199a-5p/3p; miR-98-5p; miR-103a-3p; miR-107; miR-30c-5p; miR-18a-5p; miR-326; miR-30b-5p; let-7f-5p |
| Huang et al []42 | 2023 | Serum | miR-21; miR-27a; miR-93; miR-221; miR-222; miR-223 | – |
| Huo et al []43 | 2022 | Serum | miR-486-5p; miR-6088; miR-122-5p | miR-223-3p |
| Chuang et al []45 | 2015 | Adipose tissue | miR-223 | – |
| Wang et al []48 | 2022 | Serum | miR-222-3p | – |
| Jiang et al []50 | 2016 | Serum | miR-122; miR-193b; miR-194 | – |
| Hu et al []51 | 2020 | Granulosa cells | hsa-miR-612; hsa-miR-4449; hsa-miR-4488; hsa-miR-6510-5p; hsa-miR-548ar-3p; hsa-miR-3656; hsa-miR-7110-5p; hsa-miR-4516; hsa-miR-4492; hsa-miR-3162-3p; hsa-miR-3141; hsa-miR-3195; hsa-miR-6087; hsa-miR-1273g-3; hsa-miR-3196 | hsa-miR-548aq-3p; hsa-miR-122-5p; hsa-miR-548t-5p; hsa-miR-3591-3p; hsa-miR-204-3p; hsa-miR-767-5p; hsa-miR-107; hsa-miR-33a-5p; hsa-miR-802; hsa-miR-548aj-5p; hsa-miR-190b; hsa-miR-103a-2-5p; hsa-let-7g-3p; hsa-miR-548g-5p; hsa-miR-590-5p; hsa-miR-105-5p; hsa-miR-585-3p; hsa-miR-144-3p; hsa-miR-199b-3p; hsa-miR-1298-5p; hsa-miR-20b-5p; hsa-miR-181c-5p; hsa-miR-6511b-3p; hsa-miR-126-5p; hsa-miR-378d; hsa-miR-29b-2-5p; hsa-miR-18b-5p; hsa-miR-3144-3p; hsa-miR-1255b-5p; hsa-miR-144-5p; hsa-miR-16-1-3p; hsa-miR-9-3p; hsa-miR-196b-5p; hsa-miR-34a-3p; hsa-miR-7114-5p; hsa-miR-3135b; hsa-miR-592 |
| Krentowska et al []55 | 2024 | Serum | miR-27a | miR-320 |
| Liu et al []56 | 2023 | Serum | miR-4488 | – |
| Rashad et al []58 | 2019 | Serum | – | miR-320 |
| Wander et al []60 | 2022 | Serum | miR-132-3p | miR-486-5p; miR-503-5p; miR-16-5p; miR-4732-5p/3p; miR-363-3p; miR-25-3p; miR-451a; miR-20b-5p; miR-15a-5p; miR-92-3p; miR-144-3p; miR-7-5p |
| Sang et al []61 | 2023 | Serum | – | miR-363-3p |
| Díaz et al []62 | 2020 | Serum | – | miR-451a; miR-652-3p; miR-106b-5p; miR-206 |
| Wu et al []65 | 2014 | Adipose tissue | miR-25; miR-106b | – |
| Xu et al []66 | 2023 | Granulosa cells | miR-1298-5p | – |
| Gao et al []67 | 2022 | Serum | miR-184; miR-326 | – |
| Nanda et al []68 | 2020 | Serum | – | miR-24 |
| Udesen et al []69 | 2023 | Serum | – | miR-342-3p |
| Zhang et al []70 | 2023 | Serum | – | miR-335-5p |
| Mu et al []71 | 2021 | Ovarian tissues of rats | miR-103 | – |
| Soyman et al []72 | 2022 | Serum | – | miR-132 |
| Sørensen et al []73 | 2019 | Serum | – | miR-1225-5p |
| Yang et al []74 | 2018 | Ovarian tissues of rats | miR-33b-5p | – |
| miRNA, miR – microRNA; hsa-miR – microRNA. | ||||