22 December 2024 : Review article
MicroRNAs as Biomarkers for Metabolic Disorders in Polycystic Ovary Syndrome (PCOS): A Review
Izabela Dymanowska ABCDEF 1, Karolina Frankowska
ABCDEF 2*, Agata Małgorzata Krawczyk ABCDEF 2, Julia Kociuba BCDE 2, Paulina Gil-Kulik ABCDEF 3, Beata Banaszewska ABCDEF 4, Grzegorz Polak ABCDEFG 1
DOI: 10.12659/MSM.946480
Med Sci Monit 2024; 30:e946480
Introduction
miRNAs in Insulin Resistance (IR)
miRNAs in Obesity
Lipid Metabolism Disorders Characteristic of Polycystic Ovary Syndrome (PCOS)
microRNAs in Triglycerides (TG) Metabolism Disorders
microRNAs in Total Cholesterol (TC) Metabolism Disorders
microRNAs in Low-Density Lipoprotein Cholesterol (LDL-C) Disorders
microRNAs in High-Density Lipoprotein Cholesterol (HDL-C) Disorders
microRNAs in Hypertension
microRNAs in type 2 Diabetes Mellitus
microRNAs in Non-Alcoholic Fatty Liver Disease (NAFLD)
Future Directions
Conclusions
References
Table 2 Associations between dysregulated microRNAs (miRNAs) and various indicators of excessive body weight including body mass index (BMI), waist-hip ratio (WHR), and waist circumference in patients with polycystic ovary syndrome (PCOS).
| Authors | Year | Collected material | Assessed parameter of obesity | Upregulated miRNA | Downregulated miRNA |
|---|---|---|---|---|---|
| Murri et al []41 | 2018 | Serum | BMI | miR-24-3p; miR-122-5p; miR-1537; miR-140-5p; miR-148a-3p; miR-223-5p; miR-23a-3p; miR-29c-3p; miR-30e-5p; miR-338-3p; miR-361-5p; miR-365a-3p; miR-378a-5p; miR-424-5p; miR-425-3p; miR-425-5p; miR-877-5p; miR-197-3p; miR-223-3p | miR-151a-3p; miR-151a-5p; let-7d-5p; miR-199a-3p; miR-199a-5p; miR-199b-5p; miR-379-3p |
| WHR | miR-192-5p; miR-193a-5p; miR-203a; miR-122-5p; miR-378a-5p; miR-877-5p | miR-151a-3p; miR-151a-5p; miR-199a-3p; miR-199a-5p; miR-181a-2-3p; miR-30d-3p; miR-331-3p; miR-98-5p; miR-30b-5p; miR-326; miR-126-5p | |||
| Wander et al []60 | 2022 | Serum | Waist circumference | miR-326; miR-339-5p | miR-1294; miR-4732-5p; miR-451a; miR-486-5p; miR-16-5p; miR-15a-3p; miR-451b; miR-4732-3p; miR-1180-3p |
| Xu et al []66 | 2023 | Granulosa cells | BMI | miR-1298-5p | – |
| WHR | |||||
| Gao et al []67 | 2022 | Serum | BMI | miR-184; miR-326 | – |
| Nanda et al []68 | 2020 | Serum | BMI | – | miR-24 |
| Udesen et al []69 | 2023 | Serum | WHR | miR-376-3p | - |
| Zhang et al []70 | 2023 | Serum | BMI | – | miR-335-5p |
| Udesen et al []75 | 2020 | Serum | BMI | miR-122; miR-223 | – |
| Zhao et al [][]76 | 2015 | Serum | BMI | miR-223 | – |
| Murri et al []78 | 2013 | Serum | BMI | miR-21; miR-27b; miR-103; miR-155 | – |
| Xiong et al []79 | 2017 | Serum | BMI | miR-23a | – |
| Lin et al []80 | 2020 | Serum | BMI | miR-23a | – |
| Romero-Ruiz et al []86 | 2021 | Serum | BMI | miR-33a-5p; miR-143-3p | – |
| Yang et al []87 | 2022 | Granulosa cells | BMI | miR-133a-3p | – |
| Cirillo et al []88 | 2019 | Granulosa cells | BMI | – | miR-486 |
| miRNA, miR – microRNA; hsa-miR – microRNA; BMI – body mass index; WHR –waist-hip ratio. | |||||