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14 May 2025 : Clinical Research  

Efficacy of Prolotherapy for Temporomandibular Joint Dysfunction: An Interventional Clinical Study

Khalil Assiri ORCID logo AG 1, Abdullah Alqarni ORCID logo AF 1, Hussain Almubarak DF 1, Sultan Mohammed Kaleem ORCID logo ABEF 1*, Saeed Alassiri BCE 1, Fawaz Abdul Hamid Baig ABF 2, Ajmal Muhammed BD 1, Mohammad Zahir Kota BF 2, Ali Azhar Dawasaz BE 1, Ali Mosfer Alqahtani CD 1, Hassan Ahmed Assiri ORCID logo CD 1, Saeed Abdullah Arem ORCID logo DF 1, Salma Abubaker Abbas Ali CF 1, Master Luqman Mannakandath DF 1

DOI: 10.12659/MSM.946650

Med Sci Monit 2025; 31:e946650

Table 1 Patient characteristics prior to prolotherapy.

CharacteristicsMalesFemalesTotalPercentile
TMJ Patients13 (52%)12 (48%)25100%
Number patients who visited other medical doctors for the complaint1 (7.6%)2 (16.6%)312%
Years of pain & suffering3 >2yrs10 <1yr5 >2yrs7 <1yr8 >2yrs17 <1yr32% >2yr68% <1yr
Patients with surgery only option3 (23%)6 (50%)936%
Took one drug for pain management10 (77%)7 (58%)1768%
Took two or more pharm drugs for pain3 (23%)6 (50%)936%
No. of patients opted for prolotherapy procedure5 (38.4%)2 (16.6%)728%
No. of patients opted out prolotherapy8 (61.5%)10 (83.3%)1872%

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750