14 May 2025 : Clinical Research
Efficacy of Prolotherapy for Temporomandibular Joint Dysfunction: An Interventional Clinical Study
Khalil Assiri
AG 1, Abdullah Alqarni AF 1, Hussain Almubarak DF 1, Sultan Mohammed Kaleem ABEF 1*, Saeed Alassiri BCE 1, Fawaz Abdul Hamid Baig ABF 2, Ajmal Muhammed BD 1, Mohammad Zahir Kota BF 2, Ali Azhar Dawasaz BE 1, Ali Mosfer Alqahtani CD 1, Hassan Ahmed Assiri CD 1, Saeed Abdullah Arem DF 1, Salma Abubaker Abbas Ali CF 1, Master Luqman Mannakandath DF 1
DOI: 10.12659/MSM.946650
Med Sci Monit 2025; 31:e946650
Table 2 Symptom variables in patients with temporomandibular disorders and patients opting for the prolotherapy procedure.
| Study variables | N=25 | % | n | (N-n%) | COR | P-value |
|---|---|---|---|---|---|---|
| Clicking and popping | 13 | 52% | 25–13=12 | 48% | 1.16 | – |
| Restricted mouth opening | 16 | 64% | 25–16=9 | 36% | 0.3 | – |
| Deviation and jerks | 5 | 20% | 25–5=20 | 80% | 0.5 | – |
| Pre-auricular tenderness | 16 | 64% | 25–16=9 | 36% | 0.3 | – |
| Intra-auricular tenderness | 10 | 40% | 25–10 =15 | 60% | 1.71 | – |
| Crepitus | 8 | 32% | 25–8= 17 | 68% | 1.48 | – |
| Pain in muscles of mastication | 11 | 44% | 25–11=14 | 56% | 1.31 | – |
| Subjects who opted for prolotherapy | 7 | 28% | 25–7=18 | 72% | 0.29 | 4.76 |
| 95% Confidence interval | 8.3 to 14 | 10.1 to 16.6 | – | 0.49 to1.4 | – | |
| P-value of 4.7 not significant in terms of symptom variables and subjects opting for prolotherapy procedure, this is because of anxiety, apprehension and fear psychos among the subjects who are opting out. Crude’s odd ratio range from 0.49 to 1.4 which kneels towards disparity between the subjects. | ||||||