06 February 2025 : Clinical Research
Effects of Herpesviruses on Proinflammatory Cytokines in Chronic Periapical Lesions
Jelena Popović
ABCDEF 1*, Tatjana Cvetković ACDEF 2, Tanja Džopalić CDEF 3, Antonije Stanković CDEF 4, Marija Nikolić BCF 4, Aleksandar Mitić BEF 4, Kosta Todorović BDE 5, Nenad Stošić DEF 4, Radomir Barac DEF 4, Jelena Milasin ACDEFG 6
DOI: 10.12659/MSM.946843
Med Sci Monit 2025; 31:e946843
Table 1 HCMV and EBV detection in symptomatic and asymptomatic periapical lesions.
| Virus | Symptomatic | Asymptomatic | Chi-square cross-table with Herpesvirus-negative |
|---|---|---|---|
| Herpesvirus-negative | 14 (32.6%) | 24 (66.6%) | / |
| HCMV-positive | 15 (34.9%) | 8 (22.2%) | χ=4.63; p=0.031 |
| EBV-positive | 5 (11.6%) | 2 (5.6%) | χ2=2.9; p=0.089 |
| HCMV/EBV-positive | 9 (20.9%) | 2 (5.6%) | χ2=6.93; p=0.008* |
| Total | 43 (100%) | 36 (100%) | / |
| HCMV – human cytomegalovirus; EBV – Epstein-Barr virus;χ – Chi-square test value; – the probability value; * – statistical significance at | |||