06 February 2025 : Clinical Research
Effects of Herpesviruses on Proinflammatory Cytokines in Chronic Periapical Lesions
Jelena Popović
ABCDEF 1*, Tatjana Cvetković ACDEF 2, Tanja Džopalić CDEF 3, Antonije Stanković CDEF 4, Marija Nikolić BCF 4, Aleksandar Mitić BEF 4, Kosta Todorović BDE 5, Nenad Stošić DEF 4, Radomir Barac DEF 4, Jelena Milasin ACDEFG 6
DOI: 10.12659/MSM.946843
Med Sci Monit 2025; 31:e946843
Table 2 Values of cytokine concentrations in the analyzed periapical lesions.
| Virus | 1. None | 2. CMV | 3. EBV | 4. CMV+EBV | ANOVA | Post hoc Tukey p<0.05 | |
|---|---|---|---|---|---|---|---|
| IL-6 | S | 803.37±156.73 | 2042.2±143.47 | 2087.49±120.92 | 2955.65±298.52 | F=255.23p<0.001* | 1 vs 2, 1 vs 3, 1 vs 4, 2 vs 4 |
| A | 369.35±151.42 | 1180.93±178.49 | 1444.83±134.94 | 1557.55±312.5 | F=86.6p<0.001* | 1 vs 2, 1 vs 3, 1 vs 4, 2 vs 4 | |
| Studen t-test | t=8.42p<0.001* | t=12.61p<0.001* | t=6.2p=0.002** | t=5.96p<0.001* | |||
| IL-8 | S | 2064.86±377.33 | 2813.11±178.9 | 4131.18±197.29 | 4277.15±448.35 | F=108.18p<0.001* | 1 vs 2, 1 vs 3 1 vs 4, 2 vs 3, 2 vs 4 |
| A | 1178.43±197.06 | 1854.49±187.09 | 2296.2±210.25 | 2565.69±170.87 | F=61.53p<0.001* | 1 vs 2, 1 vs 3, 1 vs 4, 2 vs 3, 2 vs 4 | |
| Studen t-test | t=9.55p<0.001* | t=12.05p<0.001* | t=10.97p<0.001* | t=5.113p=0.001** | |||
| TNF-α | S | 8.9±1.55 | 12.49±1.96 | 14.52±1.5 | 17.89±6.62 | F=13.48p<0.001* | 1 vs 2, 1 vs 3, 1 vs 4, 2 vs 4 |
| A | 7.52±1.07 | 9.41±1.5 | 11.21±0.77 | 11.44±0.54 | F=15.12p<0.001* | 1 vs 2, 1 vs 3, 1 vs 4 | |
| Studen t-test | t=3.23p=0.003** | t=3.86p=0.001** | t=2.85p=0.036** | t=1.32p=0.219 | |||
| TGF-β | S | 2248.3±240.018 | 2707.16±289.33 | 2694.42±162.25 | 2955.65±298.52 | F=14.637p<0.001 | 1 vs 2, 1 vs 3, 1 vs 4 |
| A | 2003.39±277.58 | 2200.01±467.29 | 2549.82±833.42 | 2902.17±1431.45 | F=3.474p=0.027 | 1 vs 4 | |
| Studen t-test | t=2.75p=0.009** | t=3.23p=0.004** | t=0.432p=0.684 | t=0.123p=0.904 | |||
| HCMV – human cytomegalovirus; EBV – Epstein-Barr virus; S – symptomatic lesions; A – asymptomatic lesions; IL-6 – interleukin 6; IL-8 – interleukin 8; TNF-α – tumor necrosis factor-alpha; TGFβ-1 – transforming growth factor beta-1; t – independent sample t-test value; F – ANOVA test value; p – the probability value; * – statistical significance at p ** – statistical significance at p | |||||||