11 May 2025 : Clinical Research
Impact of Dexmedetomidine on Analgesia and Inflammatory Response in Knee Surgery: A Study of IPACK and ACB Techniques
Jian Zeng
ABCDEFG 1, Li Zhao ABCDEF 2, Jinpei Xue ACDFG 1, Zhijun Yao CDEF 1, Xiongtiao Yang ACDF 1, Xiao Zhong BCD 1, Yulong Fu ABF 1, Jianpeng Li ABD 1, Yang Cui AB 1, Zhiqin Chen AB 1, Jiamin Zhong A 1, Hongyi Lei ACDEFG 1*
DOI: 10.12659/MSM.947087
Med Sci Monit 2025; 31:e947087
Table 2 Comparison of Postoperative VAS scores between Groups E and C.
| Standard error | Mean difference (95% CI) | P value | |
|---|---|---|---|
| Resting state | |||
| 12 h | 0.22 | −0.77 (−1.30 to −0.23) | 0.002 |
| 24 h | 0.21 | −0.91 (−1.42 to −0.41) | <0.001 |
| 48 h | 0.20 | −1.15 (−1.65 to −0.65) | <0.001 |
| 54 h | 0.18 | −0.53 (−0.98 to −0.08) | 0.015 |
| Active state | |||
| 12 h | 0.20 | −1.82 (−2.30 to −1.35) | <0.001 |
| 24 h | 0.21 | −0.71 (−1.22 to −0.20) | 0.003 |
| 48 h | 0.17 | −0.91 (−1.32 to −0.50) | <0.001 |
| Utilizing one-way analysis of variance (ANOVA), followed by the Bonferroni correction for multiple tests. VAS – Visual Analog Scale; h – hours. Group E, DEX local anesthetic adjuvant. Group C, blank control. Group E, perineural DEX adjuvant+IPACK+ACB. Group I, intravenous DEX+IPACK+ACB. Group C, (IPACK+ACB) control group. | |||