11 May 2025 : Clinical Research
Impact of Dexmedetomidine on Analgesia and Inflammatory Response in Knee Surgery: A Study of IPACK and ACB Techniques
Jian Zeng
ABCDEFG 1, Li Zhao ABCDEF 2, Jinpei Xue ACDFG 1, Zhijun Yao CDEF 1, Xiongtiao Yang ACDF 1, Xiao Zhong BCD 1, Yulong Fu ABF 1, Jianpeng Li ABD 1, Yang Cui AB 1, Zhiqin Chen AB 1, Jiamin Zhong A 1, Hongyi Lei ACDEFG 1*
DOI: 10.12659/MSM.947087
Med Sci Monit 2025; 31:e947087
Table 3 The difference value of inflammatory factors between the first day after surgery and before surgery in the 3 groups (mean±SD).
| Project | Group E (n=34) | Group I (n=33) | Group C (n=34) | H | P value |
|---|---|---|---|---|---|
| (&) IL-1β | 0.07±0.83* | −0.69±1.36# | 1.54±3.86 | 19.06 | <0.001 |
| (&) IL-6 | 4.21±6.34 | 1.03±13.51 | 8.31±20.91 | 1.17 | 0.558 |
| (&) TNF-α | 0.29±3.12 | −2.18±8.84# | 2.01±5.61 | 9.99 | 0.007 |
| We used the independent-samples Kruskal-Wallis test to check for differences between groups. # Indicates comparison with Group C, * Comparison with Group I, (&) indicates difference value of inflammatory factors between the first day after surgery and before surgery. H stands for statistic. Group E, perineural DEX adjuvant+IPACK+ACB. Group I, intravenous DEX+IPACK+ACB. Group C, (IPACK+ACB) control group. | |||||