11 May 2025 : Clinical Research
Impact of Dexmedetomidine on Analgesia and Inflammatory Response in Knee Surgery: A Study of IPACK and ACB Techniques
Jian Zeng
ABCDEFG 1, Li Zhao ABCDEF 2, Jinpei Xue ACDFG 1, Zhijun Yao CDEF 1, Xiongtiao Yang ACDF 1, Xiao Zhong BCD 1, Yulong Fu ABF 1, Jianpeng Li ABD 1, Yang Cui AB 1, Zhiqin Chen AB 1, Jiamin Zhong A 1, Hongyi Lei ACDEFG 1*
DOI: 10.12659/MSM.947087
Med Sci Monit 2025; 31:e947087
Table 4 Frequency of postoperative rescue analgesia and the dose oral analgesics administered at 1-week after discharge in the 3 groups [(%), (mean±SD)].
| Project | Group E (n=34) | Group I (n=33) | Group C (n=34) | F/χ2 | P value |
|---|---|---|---|---|---|
| PD1b | 2 (5.9) | 6 (18.2) | 8 (23.5) | 2.111 | 0.127 |
| PD2b | 2 (5.9) | 7 (21.2) | 18 (52.9) | 12.087 | <0.001 |
| 1-week discharge analgesics (capsules)a | 2.32±1.77 | 2.64±1.71 | 2.59±2.05 | 0.280 | 0.757 |
| a Single-factor ANOVA; b χ tests. PD1, Number of rescues and analgesia on the first day after surgery. PD2, Number of rescues and analgesia on the second day after surgery. The value is the comparison between groups. Group E, perineural DEX adjuvant+IPACK+ACB. Group I, intravenous DEX+IPACK+ACB. Group C, (IPACK+ACB) control group. | |||||