26 January 2025 : Clinical Research
Impact of Periodontal Treatment on Early Rheumatoid Arthritis and the Role of Porphyromonas gingivalis Antibody Titers
Yoichiro Nakajima
1ABCDEF, Nahoko Kato-Kogoe 1ABCDEF*, Takako Yasuda2ABC, Rika Urakawa2BC, Tomoka Matsuo1DF, Michi Omori1BDF, Takaaki Ueno1ADEF, Tohru Takeuchi3ADE
DOI: 10.12659/MSM.947146
Med Sci Monit 2025; 31:e947146
Table 3 Number of patients with rheumatoid arthritis at each disease activity level in each group with different timings of periodontal therapy initiation.
| Group | Disease activity level | Baseline | 3 months | 6 months | 9 months | 12 months |
|---|---|---|---|---|---|---|
| A(n=9) | Remission | 1 (11.1) | 7 (77.8) | 6 (75.0) | 5 (71.4) | 6 (75.0) |
| Low activity | 0 (0.0) | 0 (0.0) | 1 (12.5) | 0 (0.0) | 2 (25.0) | |
| Moderate activity | 6 (66.7) | 2 (22.2) | 0 (0.0) | 2 (28.6) | 0 (0.0) | |
| High activity | 2 (22.2) | 0 (0.0) | 1 (12.5) | 0 (0.0) | 0 (0.0) | |
| B(n=10) | Remission | 0 (0.0) | 3 (30.0) | 6 (60.0) | 8 (80.0) | 8 (80.0) |
| Low activity | 2 (20.0) | 1 (10.0) | 1 (10.0) | 1 (10.0) | 0 (0.0) | |
| Moderate activity | 4 (40.0) | 5 (50.0) | 2 (20.0) | 1 (10.0) | 2 (20.0) | |
| High activity | 4 (40.0) | 1 (10.0) | 1 (10.0) | 0 (0.0) | 0 (0.0) | |
| C(n=11) | Remission | 3 (27.3) | 6 (54.5) | 6 (54.5) | 5 (50.0) | 5 (45.5) |
| Low activity | 3 (27.3) | 2 (18.2) | 0 (0.0) | 1 (10.0) | 3 (27.3) | |
| Moderate activity | 4 (36.4) | 3 (27.3) | 5 (45.5) | 3 (30.0) | 3 (27.3) | |
| High activity | 1 (9.1) | 0 (0.0) | 0 (0.0) | 1 (10.0) | 0 (0.0) | |
| Results are expressed as n (%). Remission (DAS28-CRP 4.1). DAS28-CRP – disease activity score including 28 joints using C-reactive protein. | ||||||