Impact of Periodontal Treatment on Early Rheumatoid Arthritis and the Role of Porphyromonas gingivalis Antibody Titers

26 January 2025 : Clinical Research

Yoichiro Nakajima

^1ABCDEF, Nahoko Kato-Kogoe

^1ABCDEF*, Takako Yasuda^2ABC, Rika Urakawa^2BC, Tomoka Matsuo^1DF, Michi Omori^1BDF, Takaaki Ueno^1ADEF, Tohru Takeuchi^3ADE

DOI: 10.12659/MSM.947146

Med Sci Monit 2025; 31:e947146

Introduction Material and Methods Results Discussion Conclusions References

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Table 5 Number of patients with rheumatoid arthritis at each disease activity level in each Porphyromonas gingivalis antibody titer group.

P. gingivalis antibody titer group	Disease activity level	Baseline	12 months	P value
Low (n=8)	Remission	1 (12.5)	3 (37.5)	0.334
	Low activity	2 (25.0)	1 (12.5)
	Moderate activity	4 (50.0)	4 (50.0)
	High activity	1 (12.5)	0 (0.0)
Medium (n=14)	Remission	3 (21.4)	10 (76.9)	0.006^**
	Low activity	1 (7.1)	2 (15.4)
	Moderate activity	5 (35.7)	1 (7.7)
	High activity	5 (35.7)	0 (0.0)
High (n=8)	Remission	0 (0.0)	6 (75.0)	0.010^*
	Low activity	2 (25.0)	2 (25.0)
	Moderate activity	5 (62.5)	0 (0.0)
	High activity	1 (12.5)	0 (0.0)
Results are expressed as n (%). Remission (DAS28-CRP 4.1). ^* ^** Significantly different between baseline and 12month (Wilcoxon signed rank test). DAS28-CRP – disease activity score including 28 joints using C-reactive protein.

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