Effects of Weight Loss on Insulin Resistance and Liver Health in T2DM and NAFLD Patients

16 June 2025 : Clinical Research

Xu Yang^{ACDF 1*}, Qifang Meng^{BDEG 1}, Pingyu Wu^{BCF 1}

DOI: 10.12659/MSM.947157

Med Sci Monit 2025; 31:e947157

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Table 3 Laboratory parameter changes pre- and post-intervention.

	Group A (n=11)			Group B (n=26)
	Begin	Final	P	Begin	Final	P
TBIL (μmol/L)	14.95±7.97	14.65±7.93	>0.05	16.82±9.90	15.78±9.01	<0.001
AST (U/L)	46.64±25.29	44.73 ±23.06	>0.05	57.73±31.57	51.54 ±27.35	<0.001
ALT (U/L)	98.27±71.13	95.73±66.84	>0.05	115.42±63.28	103.19±55.39	<0.001
LDH (U/L)	202.09±71.45	195.00±64.73	>0.05	207.67±44.78	199.38±31.27	>0.05
ALP (U/L)	94.27±21.57	91.18±14.81	>0.05	89.77±28.73	84.81±20.24	>0.05
GGT.γ (U/L)	120.64±66.98	114.91±60.44	>0.05	108.77±88.51	102.50±73.83	>0.05
TG (mmol/L)	4.32±2.30	3.67±1.89	<0.05	4.49±3.58	3.48±2.83	<0.001
TC (mmol/L)	5.36±1.09	5.14±1.12	<0.05	4.89±1.21	4.31±0.94	<0.001
LDL-c (mmol/L)	3.49±1.16	3.38±1.12	<0.05	3.08±0.84	2.86±0.83	<0.001
HDL-c (mmol/L)	1.04±0.19	1.07±0.16	>0.05	0.99±0.23	1.13±0.25	<0.001
FBG	7.17±2.18	6.47±1.58	<0.05	7.25±2.23	6.64±1.51	<0.05
HOMA-IR	5.35±3.97	4.25±2.74	<0.05	5.67±3.65	3.90±2.07	<0.001
(MRI) Liver fat content	16.45±9.22	14.36±8.12	<0.05	14.92±6.21	12.54±5.29	<0.001
Values are expressed as mean±SD. P≤0.05 (Wilcoxon test).

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