04 February 2025 : Clinical Research
Serum Trimethylamine N-Oxide Levels as a Predictor of Peripheral Arterial Disease in Kidney Transplant Recipients
Hsiao-Hui Yang
ABCDEFG 1,2,3, Yen-Cheng Chen ABDFG 1,2, Chin-Hung Liu BCD 4,5, Bang-Gee Hsu ABCDEFG 2,3,6*
DOI: 10.12659/MSM.947197
Med Sci Monit 2025; 31:e947197
Table 2 Multivariable logistic regression investigation of serum trimethylamine N-oxide levels for peripheral artery disease among 98 kidney transplantation recipients.
| TMAO (μg/L) | Unadjusted | Model 1 | Model 2 | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P value | aOR (95% CI) | P value | aOR (95% CI) | P value | |
| Per 1 μg/L TMAO increase | 1.106 (1.044–1.172) | 0.001* | 1.118 (1.050–1.191) | <0.001* | 1.154 (1.062–1.255) | 0.001* |
| Model 1 is adjusted for age, diabetes mellitus, hypertension, sex, body mass index, and kidney transplantation duration. Model 2 is adjusted for the Model 1 variables and for systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, fasting glucose, estimated glomerular filtration rate and intact parathyroid hormone. TMAO – trimethylamine -oxide; OR – odds ratio; aOR – adjusted odds ratio. * | ||||||