04 February 2025 : Clinical Research
Serum Trimethylamine N-Oxide Levels as a Predictor of Peripheral Arterial Disease in Kidney Transplant Recipients
Hsiao-Hui Yang
ABCDEFG 1,2,3, Yen-Cheng Chen ABDFG 1,2, Chin-Hung Liu BCD 4,5, Bang-Gee Hsu ABCDEFG 2,3,6*
DOI: 10.12659/MSM.947197
Med Sci Monit 2025; 31:e947197
Table 3 Spearman correlation coefficients between serum log-transformed trimethylamine N-oxide levels and clinical variables in 98 kidney transplantation recipients.
| Variables | Spearman coefficient of correlation | P Value |
|---|---|---|
| Age (years) | 0.104 | 0.307 |
| Body mass index (kg/m) | 0.145 | 0.153 |
| Post-KT duration (months) | −0.008 | 0.939 |
| Left ankle-brachial index | −0.476 | <0.001* |
| Right ankle-brachial index | −0.532 | <0.001* |
| Total cholesterol (mg/dL) | 0.096 | 0.347 |
| HDL-C (mg/dL) | 0.020 | 0.843 |
| LDL-C (mg/dL) | 0.128 | 0.212 |
| Log-triglyceride (mg/dL) | −0.019 | 0.557 |
| Log-glucose (mg/dL) | −0.053 | 0.606 |
| eGFR (mL/min) | −0.281 | 0.005* |
| Log-iPTH (pg/mL) | −0.106 | 0.298 |
| Data of TMAO, triglyceride, glucose, and iPTH levels showed skewed distribution and therefore were log-transformed before analysis. Analysis of data was performed using the Spearman correlation analysis. KT – kidney transplantation; TMAO – trimethylamine -oxide; eGFR – estimated glomerular filtration rate; iPTH – intact parathyroid hormone. * | ||