Associations Between Dopamine Beta-Hydroxylase Gene Polymorphisms and Restless Legs Syndrome: A Case-Control Study

23 August 2025 : Clinical Research

Fatma Ebru Algül

^{ACEF 1*}, Sinan Tatli

^{BDE 2}, Elif Yesilada

^{ADE 3}

DOI: 10.12659/MSM.947267

Med Sci Monit 2025; 31:e947267

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Table 1 The demographic and clinic characteristics of patients and controls.

	Patients (n=103)	Controls (n=100)	P
Age (years)^*	54.41±15.56 (21–90)	50.08±17.80 (22–78)	0.066^a
Gender (Female /Male )	70/33	49/51	0.007,^b
RLS severity
Mild	45 (43.7)
Moderate	27 (26.2)
Severe	15 (14.6)
Very severe	16 (15.5)
Age of onset (years)^*	50.25±15.02 (20–89)
Disease duration (month)^*	49.42±60.31 (1–360)
Family history
Presence	5 (4.9)
Absence	98 (95.1)
RLS – restless legs syndrome. ^* Data is mean±SD (minimum–maximum); ^# Statistically significant (p ^a Independent sample t-test; ^b Pearson chi-square test.

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