Associations Between Dopamine Beta-Hydroxylase Gene Polymorphisms and Restless Legs Syndrome: A Case-Control Study

23 August 2025 : Clinical Research

Fatma Ebru Algül

^{ACEF 1*}, Sinan Tatli

^{BDE 2}, Elif Yesilada

^{ADE 3}

DOI: 10.12659/MSM.947267

Med Sci Monit 2025; 31:e947267

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Table 2 Comparisons of DBH RS129882, RS732833, RS1611115 genotype and allele distributions.

	RLS	Control	P
			0.514^a
CC	60 (58.3)	54 (54.0)
CT	38 (36.9)	37 (37.0)
TT	5 (4.9)	9 (9.0)
			0.362^a
C	158 (76.6)	145 (72.5)
T	48 (23.4)	55 (27.5)
			0.015,^a
CC	39 (37.9)	43 (43.0)	0.456^a
CT	57 (55.3)	39 (39.0)	0.02,^a
TT	7 (6.8)	18 (18.0)	0.015,^a
			0.536^a
C	135 (65.5)	125 (62.5)
T	71 (34.5)	75 (37.5)
			0.267a
CC	63 (61.2)	52 (52.0)
CT	32 (31.1)	42 (42.0)
TT	8 (7.8)	6 (6.0)
			0.424^a
C	158 (76.6)	146 (73.0)
T	48 (23.4)	54 (27.0)
RLS – restless legs syndrome. ^# Statistically significant (p ^a Pearson chi-square test.

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