23 August 2025 : Clinical Research
Associations Between Dopamine Beta-Hydroxylase Gene Polymorphisms and Restless Legs Syndrome: A Case-Control Study
Fatma Ebru Algül
ACEF 1*, Sinan Tatli BDE 2, Elif Yesilada ADE 3
DOI: 10.12659/MSM.947267
Med Sci Monit 2025; 31:e947267
Table 5 Clinical characteristics of RLS patients in DBH RS1611115 polymorphisms.
| RS1611115-Genotype | RS1611115-Allel | ||||||
|---|---|---|---|---|---|---|---|
| CC | CT | TT | P | C | T | P | |
| Gender | 0.177a | 0.826b | |||||
| Female | 45 (71.4) | 18 (56.3) | 7 (87.5) | 108 (68.4) | 32 (66.7) | ||
| Male | 18 (28.6) | 14 (43.8) | 1 (12.5) | 50 (31.6) | 16 (33.3) | ||
| Age of onset* | 50.4±15.1 | 49.7±15.4 | 50.6±14.8 | 0.970c | 50.3±15.1 | 50.0±14.9 | 0.899c |
| Duration (month)* | 44.1±49.1 | 53.3±60.3 | 75.6±120.2 | 0.347c | 45.9±51.3 | 60.7±82.5 | 0.245c |
| Disease severity | 0.156a | 0.046,a | |||||
| Mild | 33 (52.4) | 11 (34.4) | 1 (12.5) | 77 (48.7) | 13 (27.7) | 0.008,a | |
| Moderate | 15 (23.8) | 9 (28.1) | 3 (37.5) | 39 (24.7) | 15 (31.3) | 0.365a | |
| Severe | 7 (11.1) | 7 (21.9) | 1 (12.5) | 21 (13.3) | 9 (18.8) | 0.348a | |
| Very severe | 8 (12.7) | 5 (15.6) | 3 (37.5) | 21 (13.3) | 11 (22.9) | 0.107a | |
| Family history | 0.162a | 0.800b | |||||
| Presence | 4 (6.3) | 0 (0) | 1 (12.5) | 8 (5.1) | 2 (4.2) | ||
| Absence | 59 (93.7) | 32 (100) | 7 (87.5) | 150 (94.9) | 46 (95.8) | ||
| * Data is mean±SD; # Statistically significant (p a Pearson chi-square test; b Fishers Exact chi-square test; c One-way analysis of variance (ANOVA). | |||||||