Associations Between Dopamine Beta-Hydroxylase Gene Polymorphisms and Restless Legs Syndrome: A Case-Control Study

23 August 2025 : Clinical Research

Fatma Ebru Algül

^{ACEF 1*}, Sinan Tatli

^{BDE 2}, Elif Yesilada

^{ADE 3}

DOI: 10.12659/MSM.947267

Med Sci Monit 2025; 31:e947267

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Table 6 Clinical characteristics of RLS patients in DBH RS129882 polymorphisms.

	RS129882-Genotype				RS129882-Allel
	CC	CT	TT	P	C	T	P
Gender				0.351^a			0.290^b
Female	39 (65.0)	26 (68.4)	5 (100)		104 (65.8)	36 (75.0)
Male	21 (35.0)	12 (31.6)	0 (0)		54 (34.2)	12 (25.0)
Age of onset^*	50.9±13.9	50.5±16.9	39.7±9.5	0.214^c	50.9±14.6	48.3±16.1	0.294^c
Duration^*	56.6±70.0	40.9±43.7	27.2±25.4	0.546^c	52.9±64.6	38.1±40.6	0.135^c
Disease severity				0.597^a			0.468^a
Mild	24 (40.0)	17 (44.7)	4 (80.0)		65 (41.1)	25 (52.1)
Moderate	18 (30.0)	9 (23.7)	0 (0)		45 (28.5)	9 (18.8)
Severe	9 (15.0)	6 (15.8)	0 (0)		24 (15.2)	6 (12.5)
Very severe	9 (15.0)	6 (15.8)	1 (20.0)		24 (15.2)	8 (16.7)
Family history				0.053^a			0.055^b
Presence	1 (1.7)	3 (7.9)	1 (20.0)		5 (3.2)	5 (10.4)
Absence	59 (98.3)	35 (92.1)	4 (80.0)		153 (96.8)	43 (89.6)
^* Data is mean±SD; ^a Pearson chi-square test; ^b Fishers Exact chi-square test; ^c One-way analysis of variance (ANOVA).

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