Associations Between Dopamine Beta-Hydroxylase Gene Polymorphisms and Restless Legs Syndrome: A Case-Control Study

23 August 2025 : Clinical Research

Fatma Ebru Algül

^{ACEF 1*}, Sinan Tatli

^{BDE 2}, Elif Yesilada

^{ADE 3}

DOI: 10.12659/MSM.947267

Med Sci Monit 2025; 31:e947267

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Table 7 Clinical characteristics of RLS patients in DBH RS732833 polymorphisms.

	RS732833-Genotype				RS732833-Allel
	CC	CT	TT	P	C	T	P
Gender				0.889^a			0.583^b
Female	25 (64.1)	40 (70.2)	5 (71.4)		90 (66.7)	50 (70.4)
Male	14 (35.9)	17 (29.8)	2 (28.6)		45 (33.3)	21 (29.6)
Age of onset^*	51.7±16.4	49.1±14.5	51.0±10.9	0.712^c	50.6±15.6	49.5±13.8	0.613^c
Duration^*	59.1±73.3	42.9±51.2	48.0±46.9	0.437^c	52.3±64.9	43.9±49.8	0.344^c
Disease severity				0.336^a			0.296^a
Mild	13 (33.3)	28 (49.1)	4 (57.1)		54 (40.0)	36 (50.7)
Moderate	11 (28.2)	15 (26.3)	9 (15.8)		37 (27.4)	17 (23.9)
Severe	5 (12.8)	9 (15.8)	1 (14.3)		19 (14.1)	11 (15.5)
Very severe	10 (25.6)	5 (8.8)	1 (14.3)		25 (18.5)	7 (9.9)
Family history				0.825^a			0.761^b
Presence	2 (5.1)	3 (5.3)	0 (0)		7 (5.2)	3 (4.2)
Absence	37 (94.9)	54 (94.7)	7 (100)		128 (94.8)	68 (95.8)
^* Data is mean±SD; ^a Pearson chi-square test; ^b Fishers Exact chi-square test; ^c One-way analysis of variance (ANOVA).

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