Antitumor Alkaloids in Tibetan Corydalis: Chemical Diversity and Pharmacological Insights

25 June 2025 : Review article

Linguo Cao^{ABE 1}, Lijun Liu^{C 2}, Yanyan Wang^{D 1}, Jiaqing Liu^{E 1}, Zuowu Xi^{EFG 3*}

DOI: 10.12659/MSM.947268

Med Sci Monit 2025; 31:e947268

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Introduction Phytochemical Research Pharmacologically Guided Q-Marker Discovery: From Compound Identification to Mechanistic Elucidation Chemotaxonomic Profiling: From Species Differentiation to Geo-Authenticity Assessment Analytical Technology Revolution: From Single-Component Quantification to Multi-Omics Integration Tradition Meets Innovation: Processing and Compatibility-Driven Q-Marker Modulation Clinical Applications Cell Cycle Arrest Induction of Tumor Cell Apoptosis Regulation of the MAPK Signaling Pathway Suppression of Tumor Angiogenesis Conclusions Future Directions References

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Table 1 The recorded documentation of Corydalis genus Tibetan medicinal materials.

No.	Efficacy	Distribution
1	Antipyretic, reduce swelling, relieve plague, promote blood circulation and remove blood stasis, detoxify, relieve pain, dispel wind and regulate Qi, etc.	Qinghai-Tibet Plateau, Tibet, Qinghai, Sichuan
2	Treating flu, pestilence, clearing heat and cooling blood, promoting blood circulation, and relieving pain	Sichuan, Qinghai, Tibet
3	Reducing fever, stopping bleeding, promoting blood circulation, and brightening the eyes	Tibet, Qinghai
4	Treating epidemic diseases, clearing hidden heat, blood heat, etc.	Sichuan, Qinghai, Tibet, Kashmir
5	Clearing pulse heat, relieving pain, promoting blood circulation and removing blood stasis, dispelling wind and brightening the eyes	Tibet, Qinghai
6	Clearing sore heat, treating poisonous sores, promoting new muscle growth, and removing scars and warts	Tibet, Sichuan, Qinghai
7	Clearing heat and detoxifying, soothing the liver and gallbladder, relieving pain and diarrhea	Sichuan, Qinghai
8	Treating heat diseases, clearing heat and detoxifying, soothing the liver and gallbladder	Qinghai, Tibet
9	Relieving fever, promoting blood circulation and removing blood stasis, clearing hidden heat	Tibet, Qinghai
10	Relieving fever, promoting blood circulation and removing blood stasis, dispelling wind and brightening the eyes	Tibet

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